SENSITIZATION TO COCAINE

这些实验的目的是检查 在用多种药物预处理后对可卡因致敏 药理学试剂。 我们的目标是评估至少 的奖励效应的变化的基础的一部分， 可卡因是由于在特定的发展差异， 神经化学系统，这反过来又是由于环境条件。 大鼠将暴露于四种化合物（尼古丁，咖啡因，可卡因或 安非他明）持续不同的时间。 我们将比较 暴露于这些化合物以改变 可卡因和自我服用这种药物的倾向。 如果 结果表明，预先暴露于某些物质可以在获得 可卡因自我管理，他们将为我们提供一个现实的 防止滥用这种化合物的方法。 我们亦会研究 神经化学基础的敏感性变化产生的 预暴露方案使用微透析探针来测量 中脑核和内侧前额叶内的细胞外多巴胺 皮层 综合起来，我们希望这条线索 将证明环境因素作为诱发因素的重要性 药物滥用，并将提供途径，导致预防这一点 强迫性自毁行为

It is the purpose of these experiments to examine the process of sensitization to cocaine following pretreatment with a number of pharmacological agents. It is our aim to evaluate the idea that at least part of the basis for variability in response to the rewarding effects of cocaine Is due to differences in the development of specific neurochemical systems, which in turn is due to environmental conditions. Rats will be exposed to four compounds (nicotine, caffeine, cocaine or amphetamine) for various periods of time. We will compare the ability for exposure to these compounds to alter the motor activating effects of cocaine and the propensity to self-administer this drug. Should the results show that preexposure to some agents can after the acquisition of cocaine self-administration, they will provide us with a realistic approach to prevention of abuse of this compound. We will also examine the neurochemical basis for changes in sensitivity produced by the preexposure regimen using microdialysis probes to measure the changes in extracellular dopamine within the nucleus accumbens and medial prefrontal cortex. Taken together, it is our hope that this line of investigation will demonstrate the importance of environmental factors as predisposing to drug abuse and will provide avenues leading to prevention of this compulsive self-destructive behavior.