SENSITIZATION TO COCAINE

这些实验的目的是检验 用多种药物对可卡因进行预处理后致敏 药理制剂。我们的目标是评估这样一个想法，即至少 响应奖励效应的可变性的一部分基础 可卡因是由于发育不同而产生的特异体 神经化学系统，而这又是由于环境条件。 大鼠将暴露于四种化合物(尼古丁、咖啡因、可卡因或 安非他命)，用于不同时期。我们将比较这些能力 暴露在这些化合物中以改变运动激活效应 可卡因和自我给药的倾向。该不该 结果表明，预先接触一些制剂后，可以获得 可卡因的自我管理，将为我们提供一个现实的 防止滥用这种化合物的方法。我们还将检查 神经化学基础引起的敏感度变化 使用微透析探头进行预暴露方案，以测量 伏核和前额内侧核内的细胞外多巴胺 大脑皮层。综上所述，我们希望这条调查路线 将证明环境因素作为诱因的重要性 药物滥用的风险，并将提供预防的途径 强迫性的自我毁灭行为。

It is the purpose of these experiments to examine the process of sensitization to cocaine following pretreatment with a number of pharmacological agents. It is our aim to evaluate the idea that at least part of the basis for variability in response to the rewarding effects of cocaine Is due to differences in the development of specific neurochemical systems, which in turn is due to environmental conditions. Rats will be exposed to four compounds (nicotine, caffeine, cocaine or amphetamine) for various periods of time. We will compare the ability for exposure to these compounds to alter the motor activating effects of cocaine and the propensity to self-administer this drug. Should the results show that preexposure to some agents can after the acquisition of cocaine self-administration, they will provide us with a realistic approach to prevention of abuse of this compound. We will also examine the neurochemical basis for changes in sensitivity produced by the preexposure regimen using microdialysis probes to measure the changes in extracellular dopamine within the nucleus accumbens and medial prefrontal cortex. Taken together, it is our hope that this line of investigation will demonstrate the importance of environmental factors as predisposing to drug abuse and will provide avenues leading to prevention of this compulsive self-destructive behavior.