SENSITIZATION TO COCAINE

对可卡因的敏感性

• 批准号: 2119100
• 负责人: SUSAN PICKETT
• 金额: $ 11.39万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2119100
• 关键词: amphetamines; biological models; caffeine; catheterization; cocaine; dopamine; drug abuse; drug administration rate /duration; drug hypersensitivity; drug interactions; frontal lobe /cortex; jugular veins; laboratory rat; microdialysis; neurochemistry; neuropharmacologic agent; nicotine; nucleus accumbens; psychomotor function; reinforcer; self destructive behavior; sensorimotor system; statistics /biometry; stimulant /agonist

It is the purpose of these experiments to examine the process of sensitization to cocaine following pretreatment with a number of pharmacological agents. It is our aim to evaluate the idea that at least part of the basis for variability in response to the rewarding effects of cocaine Is due to differences in the development of specific neurochemical systems, which in turn is due to environmental conditions. Rats will be exposed to four compounds (nicotine, caffeine, cocaine or amphetamine) for various periods of time. We will compare the ability for exposure to these compounds to alter the motor activating effects of cocaine and the propensity to self-administer this drug. Should the results show that preexposure to some agents can after the acquisition of cocaine self-administration, they will provide us with a realistic approach to prevention of abuse of this compound. We will also examine the neurochemical basis for changes in sensitivity produced by the preexposure regimen using microdialysis probes to measure the changes in extracellular dopamine within the nucleus accumbens and medial prefrontal cortex. Taken together, it is our hope that this line of investigation will demonstrate the importance of environmental factors as predisposing to drug abuse and will provide avenues leading to prevention of this compulsive self-destructive behavior.

这些实验的目的是检验……的过程

项目成果

Augmentation of the neurochemical effects of cocaine in the ventral striatum and medial prefrontal cortex following preexposure to amphetamine, but not nicotine: an in vivo microdialysis study.

预先暴露于安非他明（而非尼古丁）后可卡因在腹侧纹状体和内侧前额叶皮质中的神经化学作用增强：一项体内微透析研究。

• DOI: 10.1016/0024-3205(94)00664-4
• 发表时间: 1994
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: Horger,BA;Valadez,A;Wellman,PJ;Schenk,S
• 通讯作者: Schenk,S

Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine.

通过可卡因和咖啡因恢复已熄灭的可卡因吸食行为。

• DOI: 10.1016/0091-3057(94)90519-3
• 发表时间: 1994
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: Worley,CM;Valadez,A;Schenk,S
• 通讯作者: Schenk,S

Stimulant preexposure sensitizes rats and humans to the rewarding effects of cocaine.

兴奋剂暴露前使大鼠和人类对可卡因的奖励作用敏感。

• 发表时间: 1998
• 期刊: NIDA research monograph.
• 作者: Schenk,S;Davidson,ES
• 通讯作者: Davidson,ES

Acute and repeated exposure to caffeine: effects on reinstatement of extinguished cocaine-taking behavior in rats.

急性和反复接触咖啡因：对恢复大鼠已熄灭的可卡因服用行为的影响。

• DOI: 10.1007/bf02246406
• 发表时间: 1996
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Schenk,S;Worley,CM;McNamara,C;Valadez,A
• 通讯作者: Valadez,A

Effects of acute and repeated administration of N-methyl-D-aspartate (NMDA) into the ventral tegmental area: locomotor activating effects of NMDA and cocaine.

急性和重复给予 N-甲基-D-天冬氨酸 (NMDA) 到腹侧被盖区的影响：NMDA 和可卡因的运动激活作用。

• DOI: 10.1016/s0006-8993(97)00712-9
• 发表时间: 1997
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Schenk,S;Partridge,B
• 通讯作者: Partridge,B