DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION

牙齿神经分布和超微结构

• 批准号: 3219258
• 负责人: MARGARET READ BYERS
• 金额: $ 16.13万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 1989-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219258
• 关键词: autonomic nervous system; autoradiography; axon; cephalometry; dental development; dental radiography; innervation; mesencephalon; odontoblasts; periodontium; proline; radionuclide diagnosis; tritium

The purpose of this research is to continue to analyze sensory mechanisms in dental tissue. Since teeth primarily sense pain, these studies will improve our understanding of basic pain mechanisms. Comparisons of tooth pain receptors with those responsible for touch sensitivity will help define structural features unique to each type. Studies of developing, injured or inflamed teeth will help to understand the increased sensitivity associated with tooth maturation or with tissue damage. The response of sensory innervation to tissue healing will also be studied. Finally, analysis of sensory innervation in a variety of phylogenetic and functional types of teeth will help to understand the interactions between sensory receptors, pulp cells, dentin, enamel and specific tooth function. The following studies are proposed: Continued studies of the distribution of sensory receptors in teeth and their supporting tissues, of the ultrastructure of these receptors and of their interactions with associated cells. Electron microscopy, autoradiography, peroxidase cytochemistry, special stains, and immunohistochemical techniques will be used. Teeth of cats, rats, mice, rabbits and oppossum will be included, as well as extracted human teeth. Using rat and cat teeth, we will also study single dental receptors after functional identification; receptor location, ultrastructure and interaction with pulp cells in injured (drilled) teeth and during repair of injury; receptor structure and function in inflamed teeth; and cytochemistry of sensory receptors in normal or neurotoxin denervated teeth. The long-range objective of this work is to improve our understanding of basic cellular events underlying pain in order to improve treatment of pain.

这项研究的目的是继续分析感官机制 在牙科组织中。 由于牙齿主要感觉到疼痛，这些研究将 提高我们对基本疼痛机制的理解。 牙齿的比较 带有负责触摸灵敏度的人的疼痛受体将有助于 定义每种类型独有的结构特征。 发展的研究， 受伤或发炎的牙齿将有助于了解提高灵敏度 与牙齿成熟或组织损伤有关。 反应 还将研究对组织愈合的感觉神经。 最后， 分析多种系统发育和功能的感觉神经 牙齿的类型将有助于了解感觉之间的相互作用 受体，纸浆细胞，牙本质，搪瓷和特定的牙齿功能。 提出了以下研究：持续研究分布 牙齿中的感觉受体及其支撑组织， 这些受体的超微结构及其与相关的相互作用 细胞。 电子显微镜，放射自显影，过氧化物酶细胞化学， 将使用特殊污渍和免疫组织化学技术。 牙齿的牙齿 将包括猫，老鼠，老鼠，兔子和oppossum，以及 提取人牙。 使用大鼠和猫牙，我们还将学习单身 功能识别后的牙科受体；受体位置， 超微结构和与受伤（钻孔）牙齿中的浆细胞相互作用 在修复受伤期间；受体结构和功能发炎 牙齿正常或神经毒素中感觉受体的细胞化学 牙齿被剥落。 这项工作的远程目标是提高我们对 为了改善疼痛治疗的基本细胞事件。