THE CONNECTIONS OF THE CINGULATE GYRUS

扣带回的连接

• 批准号: 3347086
• 负责人: J. Michael Wyss
• 金额: $ 9.48万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3347086
• 关键词: autonomic nervous system; autoradiography; axon; blood pressure; brain mapping; cerebral cortex; electrodes; experimental brain lesion; fluorescent dye /probe; hippocampus; innervation; limbic system; neural information processing; neuroanatomy; neurons; neurophysiology; nontherapeutic iontophoresis; radiotracer; silver impregnation; thalamocortical tract; ultrasound blood flow measurement

In a continuing series of studies of the connections of the hippocampal formation, it has become apparent that the input of this structues is, to a large extent, mediated by the cingulate cortex. I propose to investigate the connections of this latter area in the rat by using tracing methods which employ the physiological processes of anterograde and retrograde axoplasmic transport. The anterograde tracing method of choice will be the 3H-amino acid autoradiographic method, while the retrograde tracing will be carried out using the horseradish peroxidase method and the new fluorescence dyes method for double labeling. These data will be compared with a detailed cytoarchitectonic analysis of the cingulate cortex. The use of the autoradiographic tracing method will make it possible to examine the connections of this area without involving the various fiber systems which lie within or very close to the mesial cortex. The other methods employed will be extremely useful in further enhancing our detailed knowledge of these connections. Thus, the results of these studies should be of direct relevance to our understanding of the circuitry of this area, and more importantly, they should elucidate the organization of the entire limbic system.

在一系列关于海马体连接的连续研究中 编队，很明显，这个结构的输入是，到一个 在很大程度上，是由扣带回皮质介导的。我提议调查 用示踪方法研究大鼠的后一区的联系 轴浆顺行运输和逆行运输的生理过程。 顺行示踪法的选择将是~3H-氨基酸 放射自显影方法，而逆行追踪将使用 辣根过氧化物酶法和新荧光染料法 双重标签。这些数据将与详细的细胞结构进行比较 对扣带回皮质的分析。 放射自显影示踪方法的使用将使检查成为可能 这一地区的连接不涉及各种光纤系统， 位于内侧皮质内或非常靠近内侧皮质。采用的其他方法将 对进一步加强我们对这些方面的详细了解非常有用 关系。因此，这些研究的结果应该是直接相关的。 对我们对这个区域的电路的理解，更重要的是，他们 应该能阐明整个边缘系统的组织结构。