PHYSIOLOGICAL ANALYSIS OF THE OLFACTORY PROJECTIONS

嗅觉投射的生理分析

• 批准号: 3215735
• 负责人: JOHN W SCOTT
• 金额: $ 18.17万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3215735
• 关键词: albino rat; antidromic impulse; brain mapping; chromatography; electrical potential; electrophysiology; experimental brain lesion; interneurons; medial olfactory area; neuroanatomy; olfactions; olfactory lobe; olfactory stimulus; sensory feedback; stimulus /response; synapses

Olfactory sensory coding at the olfactory bulb level is poorly understood, in spite of much new information on the anatomy and physiology of mammalian olfactory bulb local circuits. This laboratory has contributed to the information on local circuits and is now analyzing the odor responses of olfactory bulb cells in terms of local circuit interactions. The form of the neural response to odor is strongly influenced by the stimulus intensity, and it is necessary to systematically manipulate the stimulus intensity to determine whether cells can discriminate between different odors. In this work, appropriate controls of stimulus intensity will be used to study the neural response during changes in odor quality. The spatial interaction of afferents to each recorded cell will be tested by stimulation of the olfactory nerve layer. The work will test whether there are spatially organized excitatory and inhibitory influences for each recorded cell and relate these influences to the pattern of response to odor. Projection cells and interneurons will be identified by antidromic activation, by patterns of synaptic activation and by intracellular marking. An improved index of response magnitude will allow better evaluation of responses than has been possible in the past. Spatial organization of odor sensitivity at the mucosa and in the glomerular layer of the bulb is well established. The local circuits interactions of the several types of projection cells differ in ways that suggest varying sensitivity to this spatial organization. These cells also differ in their central projections. The proposed work will test the degree to which these relationships correlate with the odor quality and odor intensity responses of cells of the bulb. Olfaction is important in feeding, sexual and social behaviors in many species as well as in endocrine function. This research is significant for the understanding of odor quality and intensity coding. The potential for functionally separate central projections that may filter the sensory input in ways that are useful for specialized functions will be explored. Such specialized projection systems exist in the processing of other senses and these data may help lead to important generalizations about sensory function.

人们对嗅球水平的嗅觉编码知之甚少， 尽管关于哺乳动物的解剖学和生理学有很多新的信息 嗅球局部回路。这个实验室对 关于本地电路的信息，现在正在分析 嗅球细胞在局部回路相互作用方面。表格的形式 神经对气味的反应受到刺激的强烈影响。 强度，而且有必要系统地操纵刺激 强度来确定细胞是否可以区分不同的 气味。在这项工作中，适当控制刺激强度将是 用于研究气味质量变化时的神经反应。这个 每个记录细胞的传入的空间相互作用将通过以下方式进行测试 刺激嗅神经层。这项工作将测试是否有 是空间上有组织的兴奋性和抑制性影响 记录的细胞，并将这些影响与对 气味。投射细胞和中间神经元将被逆行识别 突触激活模式和细胞内激活 打标。改进的反应幅度指数将允许更好的 对答复的评估超过了过去的可能。 嗅觉敏感度的空间组织在粘膜和 肾小球部的肾小球层建立良好。本地电路 几种类型的投影单元的相互作用在以下方面有所不同 建议对这种空间组织有不同的敏感度。这些细胞还 它们的中心投影不同。拟议中的工作将测试 这些关系与气味质量和 鳞茎细胞的气味强度反应。 嗅觉在许多动物的进食、性行为和社会行为中都很重要 物种以及内分泌功能。本研究具有重要的现实意义 对气味质量和强度编码的理解。潜在的 在功能上分离的中央投射可以过滤感觉输入 将探索对专门职能有用的方式。是这样的 特殊的投射系统存在于处理其他感官和 这些数据可能有助于得出关于感官的重要概括。 功能。