PHYSIOLOGICAL ANALYSIS OF THE OLFACTORY PROJECTIONS

嗅觉投射的生理分析

• 批准号: 3215738
• 负责人: JOHN W SCOTT
• 金额: $ 21.17万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3215738
• 关键词: albino rat; antidromic impulse; brain mapping; chromatography; electrical potential; electrophysiology; experimental brain lesion; interneurons; medial olfactory area; neuroanatomy; olfactions; olfactory lobe; olfactory stimulus; sensory feedback; stimulus /response; synapses

Olfactory sensory coding at the olfactory bulb level is poorly understood, in spite of much new information on the anatomy and physiology of mammalian olfactory bulb local circuits. This laboratory has contributed to the information on local circuits and is now analyzing the odor responses of olfactory bulb cells in terms of local circuit interactions. The form of the neural response to odor is strongly influenced by the stimulus intensity, and it is necessary to systematically manipulate the stimulus intensity to determine whether cells can discriminate between different odors. In this work, appropriate controls of stimulus intensity will be used to study the neural response during changes in odor quality. The spatial interaction of afferents to each recorded cell will be tested by stimulation of the olfactory nerve layer. The work will test whether there are spatially organized excitatory and inhibitory influences for each recorded cell and relate these influences to the pattern of response to odor. Projection cells and interneurons will be identified by antidromic activation, by patterns of synaptic activation and by intracellular marking. An improved index of response magnitude will allow better evaluation of responses than has been possible in the past. Spatial organization of odor sensitivity at the mucosa and in the glomerular layer of the bulb is well established. The local circuits interactions of the several types of projection cells differ in ways that suggest varying sensitivity to this spatial organization. These cells also differ in their central projections. The proposed work will test the degree to which these relationships correlate with the odor quality and odor intensity responses of cells of the bulb. Olfaction is important in feeding, sexual and social behaviors in many species as well as in endocrine function. This research is significant for the understanding of odor quality and intensity coding. The potential for functionally separate central projections that may filter the sensory input in ways that are useful for specialized functions will be explored. Such specialized projection systems exist in the processing of other senses and these data may help lead to important generalizations about sensory function.

在嗅球水平上的嗅觉感觉编码知之甚少， 尽管哺乳动物的解剖学和生理学有很多新的信息， 嗅球局部回路 该实验室为 当地电路的信息，现在正在分析的气味反应， 嗅球细胞的局部回路相互作用。 的形式 对气味的神经反应受到刺激的强烈影响， 强度，并且有必要系统地操纵刺激 以确定细胞是否可以区分不同的 气味 在这项工作中，适当的控制刺激强度将是 用于研究气味质量变化过程中的神经反应。 的 每个记录细胞的传入神经的空间相互作用将通过 刺激嗅觉神经层。 这项工作将测试是否有 是空间组织的兴奋和抑制的影响， 记录的细胞，并将这些影响与响应模式联系起来， 异味 投射细胞和中间神经元将通过逆向电泳鉴定。 激活，通过突触激活模式和细胞内 标记. 改进后的反应程度指数将使 比以往任何时候都更有可能对反应进行评估。 在粘膜和胃粘膜中的气味敏感性的空间组织 球的肾小球层建立良好。 本地电路 几种类型的投射细胞的相互作用以不同的方式， 表明对这种空间组织的不同敏感性。 这些细胞还 不同的是它们的中心投影。 拟议的工作将测试 这些关系与气味质量相关的程度， 灯泡细胞的气味强度反应。 嗅觉在许多哺乳动物的进食、性行为和社会行为中起着重要作用。 物种以及内分泌功能。 这项研究对于 气味质量和强度编码的理解。 的潜力 可以过滤感觉输入的功能分离的中央投射 将探讨对专门职能有用的方式。 等 特殊的投射系统存在于其他感官的处理中， 这些数据可能有助于对感官的重要概括， 功能