Organ-on-a-Chip Glomerulus and Nephrotube Model

器官芯片肾小球和肾管模型

• 批准号: BB/N01250X/1
• 负责人: Brian Derby
• 金额: $ 25.47万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN01250X%2F1
• 关键词: Organ; Chip; Glomerulus; Nephrotube; Model

The current model for drug development requires the need for extensive animal studies. These can take years to complete and results may not accurately predict response in humans. One way forward is to develop in vitro models that mimic whole organ function, the so called organ-on-a-chip concept. The current state of the artfor the organ-on-a-chip is based on the microculture of populations of a single cell type or two different (but separated) cell populations in coculture within a device. This concept has been successfully used to create mimics of lung, kidney and gut tissue. However, this design is 2-dimensional and cannot accurately mimic organ structure. This follow on fund proposal will develop the organ-on-a-chip concept further by building a better model of organ tissue building on prior BBSRC funded work manipulating sheets of cells. This will be used to develop improved models of a kidney-on-a-chip with applications in drug toxicity testing and drug development.

目前的药物开发模式需要进行广泛的动物研究。这些可能需要数年时间才能完成，结果可能无法准确预测人类的反应。一种方法是开发模拟整个器官功能的体外模型，即所谓的器官芯片概念。芯片上器官的现有技术是基于在装置内共培养的单个细胞类型或两个不同（但分离的）细胞群的微培养。这一概念已成功地用于制造肺、肾和肠道组织的模拟物。然而，这种设计是二维的，不能准确地模拟器官结构。这一后续基金提案将进一步发展芯片上器官的概念，在BBSRC先前资助的操作细胞片的工作基础上，建立一个更好的器官组织模型。这将用于开发改进的肾芯片模型，并应用于药物毒性测试和药物开发。

项目成果

Integrating Cell Sheets for Organ-on-a-chip Applications

集成细胞片用于器官芯片应用

• DOI: 10.1016/j.procir.2017.04.018
• 发表时间: 2017
• 期刊: Procedia CIRP
• 作者: Loewenhardt W