Deciphering the allosteric mechanism of protein translocation through membranes

破译蛋白质跨膜易位的变构机制

• 批准号: BB/N015126/1
• 负责人: Ian Collinson
• 金额: $ 27.27万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN015126%2F1
• 关键词: Deciphering; allosteric; mechanism; protein; translocation

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis.

• DOI: 10.7554/elife.60669
• 发表时间: 2020-11-04
• 期刊: eLife
• 影响因子: 7.7
• 作者: Alvira S;Watkins DW;Troman L;Allen WJ;Lorriman JS;Degliesposti G;Cohen EJ;Beeby M;Daum B;Gold VA;Skehel JM;Collinson I
• 通讯作者: Collinson I

Refined measurement of SecA-driven protein transport reveals indirect coupling to ATP turnover

对 SecA 驱动的蛋白质转运的精确测量揭示了与 ATP 周转的间接耦合

• DOI: 10.1101/2020.05.08.084160
• 发表时间: 2020
• 作者: Allen W

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion.

• DOI: 10.7554/elife.77586
• 发表时间: 2022-04-29
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Allen, William J.;Corey, Robin A.;Watkins, Daniel W.;Oliveira, A. Sofia F.;Hards, Kiel;Cook, Gregory M.;Collinson, Ian
• 通讯作者: Collinson, Ian

SecA-a New Twist in the Tale.

• DOI: 10.1128/jb.00736-16
• 发表时间: 2017-01-15
• 期刊: Journal of bacteriology
• 影响因子: 3.2
• 作者: Collinson I

HDX-MS reveals nucleotide-regulated, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

HDX-MS 揭示细菌易位子 SecA 和 SecY 通道的核苷酸调节、反相关打开和关闭

• DOI: 10.1101/595553
• 发表时间: 2019
• 作者: Ahdash Z