INTRAOPERATIVE MEASURES OF VOCAL FOLD YOUNGS MODULUS

本研究将检验以下假设：术中测量 人类声带的横向（水平）杨氏模量将 改善单侧声门关闭不全的语音外科效果 声带麻痹。 现有的原型设备将被修改并 用于测量声带的杨氏（弹性）模量 通过聚四氟乙烯注射增强。 在第一阶段的研究中，Young's 注射聚四氟乙烯后，将测量患者的模量 手术。 手术后六周将测试他们的声音功能 使用视频频闪测量和感知判断。 在接下来的 阶段，接受声带增强术的患者将被随机分为 三组，他们的发声功能手术结果将是 比较。在一组中，杨氏模量值与最 第一阶段的成功手术结果将用作期间的目标值 手术。 在第二组手术中，杨氏模量 将通过经气管刺激来确定未受影响的声带 模拟正常的肌肉收缩和声门配置 发声。 然后，该模量值将用作 受影响声带的声带增大程度。 第三个 小组将作为对照组，在没有帮助的情况下进行手术 术中监测目标模量。 测量设备 然后，杨氏模量将作为术中的工具进行评估 通过比较各种声学、 声门、空气动力学、视频频闪和感知测量 手术前和手术后。

This study will test the hypothesis that intraoperative measurement of the transverse (horizontal) Young's modulus of the human vocal folds will improve phonosurgical results for glottal incompetence caused by unilateral vocal fold paralysis. An existing prototype device will be modified and used to measure Young's (elastic) modulus of the vocal folds during augmentation by Teflon injection. In the first phase of research, Young's modulus will be measured in patients after Teflon injection during their surgery. Their vocal function will then be tested six weeks after surgery using videostroboscopic measures and perceptual judgments. In the next phase, patients who receive vocal fold augmentation will be randomized into three groups and the results of their surgery on vocal function will be compared. In one group, the Young's modulus values associated with the most successful surgical results in Phase 1 will be used as target values during surgery. In the second surgical group, the Young's modulus of the unaffected vocal fold will be determined by using transtracheal stimulation to simulate normal muscular contraction and glottal configuration during phonation. This modulus value will then be used as the target for the degree of vocal fold augmentation of the affected vocal fold. The third group will serve as a control group and will have surgery without the aid of intraoperative monitoring of a target modulus. The device to measure Young's modulus will then be evaluated as a tool for intraoperative optimization of phonosurgical results by comparing various acoustic, glottographic, aerodynamic, videostroboscopic, and perceptual measures before and after surgery.