INTRAOPERATIVE MEASURES OF VOCAL FOLD YOUNGS MODULUS

术中声襞杨氏模量测量

• 批准号: 3217579
• 负责人: GERALD S. BERKE
• 金额: $ 9.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3217579
• 关键词: biomedical equipment resource; clinical biomedical equipment; laryngectomy; vocal cords; voice

This study will test the hypothesis that intraoperative measurement of the transverse (horizontal) Young's modulus of the human vocal folds will improve phonosurgical results for glottal incompetence caused by unilateral vocal fold paralysis. An existing prototype device will be modified and used to measure Young's (elastic) modulus of the vocal folds during augmentation by Teflon injection. In the first phase of research, Young's modulus will be measured in patients after Teflon injection during their surgery. Their vocal function will then be tested six weeks after surgery using videostroboscopic measures and perceptual judgments. In the next phase, patients who receive vocal fold augmentation will be randomized into three groups and the results of their surgery on vocal function will be compared. In one group, the Young's modulus values associated with the most successful surgical results in Phase 1 will be used as target values during surgery. In the second surgical group, the Young's modulus of the unaffected vocal fold will be determined by using transtracheal stimulation to simulate normal muscular contraction and glottal configuration during phonation. This modulus value will then be used as the target for the degree of vocal fold augmentation of the affected vocal fold. The third group will serve as a control group and will have surgery without the aid of intraoperative monitoring of a target modulus. The device to measure Young's modulus will then be evaluated as a tool for intraoperative optimization of phonosurgical results by comparing various acoustic, glottographic, aerodynamic, videostroboscopic, and perceptual measures before and after surgery.

本研究将检验以下假设：术中测量 人类声带的横向（水平）杨氏模量将 单侧声门闭合不全声外科治疗效果的改善 声带麻痹 现有的原型设备将被修改， 用于测量声带的杨氏（弹性）模量， 通过Teflon注入增强。 在研究的第一阶段，Young 将在Teflon注射后测量患者的模量， 手术 他们的发声功能将在手术后六周进行测试 使用视频频闪测量和感知判断。 未来 阶段，接受声带增强的患者将被随机分配到 三组和他们的手术结果对发音功能将是 比较了在一组中，与大多数人相关的杨氏模量值 第1阶段的成功手术结果将用作 手术 在第二手术组中， 未受影响的声带将通过使用经气管刺激来确定 以模拟正常的肌肉收缩和声门构型， 发声 然后，该模量值将被用作 受影响声带的声带增大程度。 第三 一组将作为对照组，在没有辅助的情况下进行手术 术中监测目标模量。 要测量的设备 然后将评估杨氏模量，作为术中测量的工具。 通过比较各种声学， 声门图、空气动力学、视频频闪和感知测量 在手术前后。