Laryngeal muscular control of voice production and quality

喉部肌肉控制声音的产生和质量

• 批准号: 9096061
• 负责人: GERALD S. BERKE
• 金额: $ 53.98万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096061
• 关键词: Acoustics; Address; Affect; Data; Diagnosis; Experimental Designs; Foundations; Future; Geometry; Health; Human; Intraoperative Monitoring; Investigation; Knowledge; Laryngeal muscle structure; Larynx; Left; Length; Life; Loudness; Measurement; Measures; Medial; Modeling; Muscle; Paresis; Pattern; Perception; Phase; Phonation; Physiology; Process; Production; Regulation; Research; Role; Selection for Treatments; Shapes; Surface; System; Thyroarytenoid Muscle; Voice; Voice Disorders; Voice Quality; Work; computer studies; cricothyroid muscle; design; digital imaging; imaging system; improved; neuromuscular; stereoscopic; vibration; vocal cord

DESCRIPTION (provided by applicant): Although it has been well accepted that vocal fold vibration and the resulting voice quality critically depend on vocal fold stiffness and geometry, the neuromuscular mechanisms regulating vocal fold stiffness and geometry still remain unclear. There has been no systematic, quantitative investigation of how and to what extent activation of laryngeal muscles, especially the interaction of the cricothyroid (CT) and thyroarytenoid (TA) muscles, affects the stiffness of the different layers of the vocal folds, and more importantly, how different stiffness conditions within the layered vocal fold affect the resulting vibration, acoustics, and voice quality. Laryngeal muscle activation also leads to simultaneous changes in vocal fold geometry, the influence of which on phonation is unclear. A better understanding of how laryngeal muscle activation regulates vocal fold stiffness and geometry and the resulting acoustics and voice quality may be useful for clinicians in the design and selection of treatment, or as part of intraoperative monitoring and assessment of treatment progress. This deficiency of understanding is largely due to the lack of an appropriate neuromuscular larynx model for conducting such systematic and quantitative investigations. Moreover, although there have been many studies focusing on either voice production or voice quality, there has been very little research exploring the cause-effect relation between physiology and perception. In this research, we propose to investigate the muscular processes of voice control in a recently-developed ex-vivo perfused living human larynx model (Berke et al., 2012), using our newly designed experimental approach (Zhang et al., 2012) that allows parametric muscle stimulation and observation of its influence on phonation in a virtually living human larynx. Computational studies are also proposed to facilitate interpretation and conceptualization of the experimental data. The two main questions to be addressed in the studies described here are: 1) What are the stiffness and geometry conditions that are required for normal phonation and how are they achieved through laryngeal muscle activation? and 2) How do left-right asymmetry in laryngeal muscle activation (commonly observed in voice disorders) affect vocal fold vibration, acoustics, and voice quality?

描述（由申请人提供）：虽然人们普遍认为声带振动和由此产生的语音质量严重依赖于声带刚度和几何形状，但调节声带刚度和几何形状的神经肌肉机制仍不清楚。对于喉肌的激活，特别是环甲肌（CT）和类甲状腺肌（TA）的相互作用，如何以及在多大程度上影响声带不同层的刚度，以及更重要的是，分层声带内不同的刚度条件如何影响所产生的振动、声学和语音质量，目前还没有系统的、定量的研究。喉部肌肉的激活也会导致声带几何形状的同时变化，其对发声的影响尚不清楚。更好地了解喉肌激活如何调节声带僵硬度和几何形状，以及由此产生的声学和声音质量，可能对临床医生设计和选择治疗方法有用，或者作为术中监测和评估治疗进展的一部分。这种理解的不足很大程度上是由于缺乏适当的神经肌肉喉部模型来进行这种系统和定量的调查。此外，虽然有很多研究关注语音产生或语音质量，但很少有研究探讨生理和感知之间的因果关系。在本研究中，我们建议使用我们新设计的实验方法（Zhang et al., 2012），在最近开发的离体灌注活人类喉部模型中研究声音控制的肌肉过程（Berke等人，2012），该方法允许参数肌肉刺激并观察其对虚拟活人类喉部发声的影响。计算研究也提出，以方便解释和概念化的实验数据。在这里描述的研究中要解决的两个主要问题是：1)正常发声所需的刚度和几何条件是什么，以及如何通过喉部肌肉激活来实现它们？2)喉肌激活的左右不对称（常见于语音障碍）如何影响声带振动、声学和语音质量？