SYNTHESIS OF MOLECULAR COMPOSITES NOVEL DENTAL MATERIALS

新型牙科材料分子复合材料的合成

• 批准号: 2130888
• 负责人: Yen Wei
• 金额: $ 12.36万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2130888
• 关键词: adhesions; biomaterial evaluation; chemical addition; chemical condensation; chemical reaction; chemical substitution; chemical synthesis; chemical transfer reaction; chemistry; composite resins; copolymer; covalent bond; crosslink; dental material wear; dental materials; glass; hardness; hydrolysis; molecular site; molecular weight; nuclear magnetic resonance spectroscopy; polyacrylate; polymerization; polymers; polymethacrylate; silicates; silicon; thermogravimetry; titanium

Three major classes of dental materials have been developed and used in dental practice: (1) inorganic/ceramic materials (e.g. amalgams and silicate cements), (2) organic polymers (e.g. polyacrylate resins) and (3) polymer composite materials in which fillers are mixed with a polymer at a macroscopic level. All of these materials, though succeeded in certain extent, have many inherent deficiencies in their dental applications. A novel class of dental materials is proposed, which covalently and uniformly incorporates organic polymers into an inorganic network at the molecular levels via a newly emerged sol-gel method. These molecular composite materials would have tailored combinations of the hardness of inorganic glasses and the toughness of organic polymers. Since the organic and inorganic components are covalently bonded and uniformly distributed in these new materials, there would be no interface problems as exist in the conventional dental composites. In this proposal, polyacrylates-SiO2-TiO2 systems are selected as typical examples for the initial studies with the view of taking advantage of well- established clinical applications of controlled molecular weights and desirable end groups such as -Si(OR)3, which is reactive in sol-gel reactions, will be synthesized by group-transfer polymerization method invented at Du Pont in 1983. Four types of telechelic polymers will be synthesized with one, two, three/four, or more reactive-Si(OR)3 groups. The telechelic polymers will then be introduced into the mixture of silicon and/or titanium tetraalkoxides followed b hydrolysis and crosslinking (densification) leading to the new molecular composite materials. This new class of materials will be characterized and tested. Depending on the nature and the ratio of the inorganic to the polymeric components, it should be superior in physical and chemical properties such as hardness, toughness, adhesion to tooth structure, resistance to wear and abrasion, stability, etc. over the existing dental materials.

三大类牙科材料已开发和应用于