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NOVEL MOLECULAR COMPOSITE DENTAL MATERIALS

新型分子复合牙科材料

基本信息

批准号：
2130889
负责人：
Yen Wei
金额：
$ 14.41万
依托单位：
DREXEL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-06-01 至 1998-03-31
项目状态：
已结题

项目摘要

The field of dental materials has benefitted greatly from basic research in inorganic, organic and polymer chemistry. Three major classes of dental materials have been developed and used in dental practice: (l) inorganic/ceramic materials (e.g. amalgams and silicate cements), (2) organic polymers (e.g. polyacrylate resins) and (3) polymer composite materials in which inorganic fillers are mixed with a polymer at a macroscopic level. All of these materials, though succeeded in some extent under constant modifications, have many inherent deficiencies in their dental applications. We have been interested in making a radical change of this situation by creating a novel class of dental materials. Funded by NIH (Grant No. ROl-DE09848) in the last 3 years, we have successfully synthesized such a class of dental materials, which covalently and uniformly incorporates organic polymers into inorganic matrices at the molecular level via the newly emerged sol-gel technology. These molecular composite materials demonstrated tailored combinations of the hardness of inorganic glasses and the toughness of organic polymers. There is no macroscopic phase separation in these materials so that the interface problems as exist in the conventional dental composites are eliminated. More excitingly, we discovered that the formation of these new materials can be achieved photochemically. This discovery is particularly important to the field of dental materials because one of the most common dental clinical practices is to cure the dental resins under ultraviolet radiation. In this proposal, we design a series of new in-depth studies to develop a fundamental understanding of the chemical/photochemical process that lead to the formation of these novel materials and to improve the synthesis and properties. Specifically, kinetic studies will be conducted on the photo-/nonphoto-catalyzed sol-gel reactions of the functionalized poly(methyl methacrylates) with the inorganic precursors silicon and/or titanium tetraalkoxides. The basic knowledge gained will be applied to design better synthetic strategies to solve the most challenging problems in the sol-gel reactions, i.e. volume shrinkage, cracking, and long curing time, all of which are highly undesirable in dental practice. The new synthesis will allow us to control and tailor the physical/chemical properties of this new class of materials even better for the dental applications. Moreover, the materials will be thoroughly characterized and tested. Their properties, such as hardness. toughness, adhesion to tooth structure, resistance to wear and abrasion, stability etc. will be directly compared with the existing dental composite materials. The success of this research will lay the foundation for future clinical application of this new class of materials.

牙科材料领域从基础研究中受益匪浅在无机、有机和聚合物化学中。三种主要类别的牙科材料已被开发并用于牙科实践：（l）无机/陶瓷材料（例如汞合金和硅酸盐水泥），（2）有机聚合物（例如聚丙烯酸酯树脂）和（3）聚合物复合材料其中无机填料与聚合物以宏观层面。所有这些材料，虽然成功地在一些在不断的修改下，有许多内在的缺陷，牙科应用。我们一直有兴趣彻底改变这种情况，创造了一种新型的牙科材料。由美国国立卫生研究院（NIH）资助。 ROl-DE 09848）在过去的3年中，我们已经成功地合成了这样的一类牙科材料，其共价且均匀地结合在分子水平上，将有机聚合物转化为无机基质，新出现的溶胶-凝胶技术。这些分子复合材料展示了无机玻璃硬度的定制组合和有机聚合物的韧性。没有宏观相这些材料中的分离使得存在界面问题在传统的牙科复合材料中被消除。更令人兴奋的是，我们发现这些新材料的形成可以通过光化学的这一发现对该领域特别重要牙科材料，因为一个最常见的牙科临床实践是在紫外线辐射下固化牙科树脂。在这个建议中，我们设计了一系列新的深入研究，对化学/光化学过程的基本理解，导致这些新材料的形成，并改善合成及性能具体而言，动力学研究将进行的光/非光催化溶胶-凝胶反应的用无机前体官能化的聚（甲基丙烯酸甲酯）硅和/或四烷氧基钛。获得的基本知识将应用于设计更好的合成策略，以解决最溶胶-凝胶反应中的挑战性问题，即体积收缩，开裂和长固化时间，所有这些都是非常不希望的，牙科诊所新的合成技术将使我们能够控制和调整这类新材料的物理/化学性质甚至更适合牙科应用。此外，材料将经过全面的鉴定和测试。它们的特性，如硬度。韧性、对牙齿结构的粘附性、耐磨性和耐磨性，稳定性等将直接与现有的牙科复合材料这项研究的成功将奠定为这类新药物的未来临床应用奠定了基础。材料.