SYNTHESIS OF MOLECULAR COMPOSITES NOVEL DENTAL MATERIALS

新型牙科材料分子复合材料的合成

• 批准号: 3223581
• 负责人: Yen Wei
• 金额: $ 12.21万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3223581
• 关键词: adhesions; biomaterial evaluation; chemical condensation; chemical reaction; chemical synthesis; chemical transfer reaction; chemistry; composite resins; copolymer; covalent bond; crosslink; dental material wear; dental materials; glass; hardness; hydrolysis; molecular site; molecular weight; nuclear magnetic resonance spectroscopy; polyacrylate; polymerization; polymers; polymethacrylate; silicates; silicon; thermogravimetry; titanium

Three major classes of dental materials have been developed and used in dental practice: (1) inorganic/ceramic materials (e.g. amalgams and silicate cements), (2) organic polymers (e.g. polyacrylate resins) and (3) polymer composite materials in which fillers are mixed with a polymer at a macroscopic level. All of these materials, though succeeded in certain extent, have many inherent deficiencies in their dental applications. A novel class of dental materials is proposed, which covalently and uniformly incorporates organic polymers into an inorganic network at the molecular levels via a newly emerged sol-gel method. These molecular composite materials would have tailored combinations of the hardness of inorganic glasses and the toughness of organic polymers. Since the organic and inorganic components are covalently bonded and uniformly distributed in these new materials, there would be no interface problems as exist in the conventional dental composites. In this proposal, polyacrylates-SiO2-TiO2 systems are selected as typical examples for the initial studies with the view of taking advantage of well- established clinical applications of controlled molecular weights and desirable end groups such as -Si(OR)3, which is reactive in sol-gel reactions, will be synthesized by group-transfer polymerization method invented at Du Pont in 1983. Four types of telechelic polymers will be synthesized with one, two, three/four, or more reactive-Si(OR)3 groups. The telechelic polymers will then be introduced into the mixture of silicon and/or titanium tetraalkoxides followed b hydrolysis and crosslinking (densification) leading to the new molecular composite materials. This new class of materials will be characterized and tested. Depending on the nature and the ratio of the inorganic to the polymeric components, it should be superior in physical and chemical properties such as hardness, toughness, adhesion to tooth structure, resistance to wear and abrasion, stability, etc. over the existing dental materials.

已开发并使用了三大类牙科材料 牙科实践：（1）无机/陶瓷材料（例如汞合金和 硅酸盐水泥），（2）有机聚合物（例如聚丙烯酸酯树脂）和（3） 聚合物复合材料，其中填料与聚合物在一定条件下混合 宏观层面。 所有这些材料虽然在某些方面取得了成功 在牙科应用中存在许多固有的缺陷。 提出了一类新型牙科材料，它通过共价键和 将有机聚合物均匀地结合到无机网络中 通过新出现的溶胶-凝胶方法在分子水平上进行研究。 这些分子 复合材料将具有定制的硬度组合 无机玻璃和有机聚合物的韧性。 由于有机 无机成分以共价键结合并均匀分布在 这些新材料，不会存在界面问题 传统牙科复合材料。 本提案选择聚丙烯酸酯-SiO2-TiO2体系作为典型 初步研究的例子，旨在充分利用 建立了控制分子量的临床应用 理想的端基，例如 -Si(OR)3，它在溶胶-凝胶中具有反应性 反应，通过基团转移聚合方法合成 1983 年由杜邦公司发明。四种类型的遥爪聚合物将被 由一个、两个、三个/四个或更多个反应性-Si(OR)3 基团合成。 然后将遥爪聚合物引入到硅的混合物中 和/或四烷氧基钛，然后水解和交联 （致密化）导致新型分子复合材料。 将对此类新型材料进行表征和测试。 根据 无机与聚合物组分的性质和比例，它 应具有优异的物理和化学性能，例如硬度、 韧性、对牙齿结构的附着力、耐磨损性、 稳定性等优于现有牙科材料。