15 NSFBIO: Excitocell: A rewired eukaryotic cell model for the analysis and design of cellular morphogenesis

15 NSFBIO：Excitocell：用于分析和设计细胞形态发生的重新连接的真核细胞模型

基本信息

批准号：
BB/P01190X/1
负责人：
Andrew Goryachev
金额：
$ 41.05万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FP01190X%2F1
关键词：
15 NSFBIO Excitocell rewired eukaryotic

项目摘要

Excitable dynamics is a fundamental example of an emergent behavior in complexsystems, which, although observed and studied by various branches of science and engineering,has received little attention in biology outside the context of the nervous system. The excitabledynamics discovered by the PIs represents a readily quantifiable cortical pattern-formingbehavior that is potentially controlled by a compact molecular module, and thus amenable tointegrated mathematical and experimental study.The PIs propose a novel synthetic biology approach to reconstitute cortical excitabilityin simplified rewired cells and in an ex vivo system with a high level of experimental control.Adopting this systems and synthetic biology approach, in contrast to top-down genetic analysis,is intended to produce an experimentally-validated model of the core physiological module.

令人兴奋的动力学是复杂系统中新兴行为的一个基本例子，尽管科学和工程的各个分支对此进行了观察和研究，但在神经系统的背景下，对生物学的关注很少。 PIS发现的兴奋性动力学代表了一项易于量化的皮质模式形成行为，潜在地由紧凑的分子模块控制，因此可融合数学和实验性研究。PIS提出了一种新型的合成生物学方法，以重新培养的兴奋性细胞，以简化的exifieled Recoriential and exifient exifient exifient exifient exifient and Vivo，并在VIV中进行实验。与自上而下的遗传分析相比，合成生物学方法旨在产生核心生理模块的实验验证模型。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network.

DOI：
10.1016/j.isci.2018.10.003
发表时间：
2018-10-26
期刊：
iScience
影响因子：
5.8
作者：
Leda M;Holland AJ;Goryachev AB
通讯作者：
Goryachev AB

Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration.

DOI：
10.1073/pnas.2300322120
发表时间：
2023-05-30
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Lavrsen, Kirstine;Rajendraprasad, Girish;Leda, Marcin;Eibes, Susana;Vitiello, Elisa;Katopodis, Vasileios;Goryachev, Andrew B.;Barisic, Marin
通讯作者：
Barisic, Marin

Type V myosin focuses the polarisome and shapes the tip of yeast cells.