Towards real-time image processing in single-particle electron microscopy

单粒子电子显微镜中的实时图像处理

• 批准号: DE170100701
• 负责人: Dr Dominika Elmlund
• 金额: $ 24.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100701
• 关键词: Towards; real; time; image; processing

This project aims to research real-time image processing of single-particle electron microscopy (SPEM) images and to study structural dynamics in both biology and materials science. SPEM is an essential tool to study the structure and dynamics of nanoscale molecules. However, the theoretical frameworks underpinning SPEM are in their early stages of development. This research is expected to enable the study of colloidal nanoparticle structures in solution and reveal the protein rearrangements that underlie secretion of bacterial proteins in two different systems a number of different bacterial species require for viability and infection.

本项目旨在研究单粒子电子显微镜（SPEM）图像的实时图像处理，并研究生物和材料科学中的结构动力学。SPEM是研究纳米分子结构和动力学的重要工具。然而，支撑SPEM的理论框架还处于发展的早期阶段。这项研究有望研究溶液中的胶体纳米颗粒结构，并揭示在两种不同系统中细菌蛋白质分泌的蛋白质重排，这是许多不同细菌物种生存和感染所需要的。