PATHOGENESIS OF INTESTINAL DYSFUNCTION IN AIDS

肠道功能障碍是发病的重要原因， 艾滋病毒感染者的死亡率。 肠道疾病为 特别是婴儿和幼儿的问题， 胃肠道在生长中的中心作用， 发展和作为入口的传染性病原体。 的 肠功能障碍的病理生理学尚未被 划定的 可能导致胃肠道疾病的因素 艾滋病毒感染者的功能障碍和营养不良包括 机会性胃肠道感染，包括细菌、病毒或 寄生虫病原体，慢性腹泻，由于肠道 需氧或厌氧细菌定植， 由于肠道获得性缺乏而摄入的营养素 酶和/或直接肠道感染HIV。 我们提出 进行一项前瞻性队列设计的肠道评估， 在围产期感染艾滋病毒的婴儿中发挥作用。 我们将获得 研究儿童的详细营养和人体测量数据 年龄和社会经济条件相匹配的对照组儿童 status. 我们还将进行详细的病毒学，寄生虫学， 粪便和肠道组织的细菌学分析 并试图将肠道感染与艾滋病毒和其他 致病菌引起胃肠功能紊乱。 我们将利用 这些分析的结果，以制定和评估干预措施， 肠功能障碍的预防和治疗 研究儿童。 成功控制肠道疾病可能 导致发病率和死亡率显著降低， 与儿童和成人的艾滋病毒感染有关。

Intestinal dysfunction is an important cause of morbidity and mortality in individuals with HIV infection. Intestinal disease is particularly a problem in infants and young children due to the central role of the gastrointestinal tract in growth and development and as a portal of entry of infectious pathogens. The pathophysiology of the intestinal dysfunction has not been delineated. Possible factors contributing to gastrointestinal dysfunction and malnutrition in HIV-infected individuals include opportunistic gastrointestinal infections with bacterial, viral or parasitic pathogens, chronic diarrhea due to intestinal colonization with aerobic or anaerobic bacteria, malabsorption of ingested nutrients due to acquired deficiencies in intestinal enzymes, and/or direct intestinal infection with HIV. We propose to perform a prospective, cohort-design evaluation of intestinal function in infants perinatally infected with HIV. We will obtain detailed nutritional and anthropometric data on the study children and on control children matched for age and socio-economic status. We will also perform detailed virological, parasitological, and bacteriological analyses of their stools and intestinal tissue and attempt to correlate intestinal infections with HIV and other pathogens with gastrointestinal dysfunction. We will utilize the results of these analyses to develop and evaluate interventions for the prevention and treatment of intestinal dysfunction in the study children. The successful control of intestinal diseases might result in a significant reduction in the morbidity and mortality associated with HIV infections in children and adults.