PATHOGENESIS OF INTESTINAL DYSFUNCTION IN AIDS

肠道功能障碍是发病和死亡的重要原因 艾滋病毒感染者的死亡率。肠道疾病是 尤其是在婴幼儿中，由于 胃肠道在生长和发育中的中心作用 发展和作为传染病病原体进入的门户。这个 肠功能障碍的病理生理机制尚未得到研究 勾勒出来的。引起胃肠道疾病的可能因素 HIV感染者的功能障碍和营养不良包括 细菌性、病毒性或机会性胃肠道感染 寄生病原体，肠道慢性腹泻 用好氧或厌氧细菌定植，吸收不良 因肠道获得性缺陷而摄入的营养物质 酶，和/或直接感染艾滋病毒的肠道。我们建议 对肠道进行前瞻性、队列设计评估 围产期感染艾滋病毒的婴儿的功能。我们将获得 关于研究儿童的详细营养和人体测量数据 对照组为年龄和社会经济状况相匹配的儿童 状态。我们还将进行详细的病毒学、寄生虫学、 粪便和肠道组织的细菌学分析 并试图将肠道感染与艾滋病毒和其他 有胃肠功能障碍的病原体。我们将利用 这些分析的结果，以开发和评估干预措施 高血压病患者肠功能障碍的防治 研究孩子们。肠道疾病的成功控制可能会 导致发病率和死亡率显著降低 与儿童和成人的艾滋病毒感染有关。

Intestinal dysfunction is an important cause of morbidity and mortality in individuals with HIV infection. Intestinal disease is particularly a problem in infants and young children due to the central role of the gastrointestinal tract in growth and development and as a portal of entry of infectious pathogens. The pathophysiology of the intestinal dysfunction has not been delineated. Possible factors contributing to gastrointestinal dysfunction and malnutrition in HIV-infected individuals include opportunistic gastrointestinal infections with bacterial, viral or parasitic pathogens, chronic diarrhea due to intestinal colonization with aerobic or anaerobic bacteria, malabsorption of ingested nutrients due to acquired deficiencies in intestinal enzymes, and/or direct intestinal infection with HIV. We propose to perform a prospective, cohort-design evaluation of intestinal function in infants perinatally infected with HIV. We will obtain detailed nutritional and anthropometric data on the study children and on control children matched for age and socio-economic status. We will also perform detailed virological, parasitological, and bacteriological analyses of their stools and intestinal tissue and attempt to correlate intestinal infections with HIV and other pathogens with gastrointestinal dysfunction. We will utilize the results of these analyses to develop and evaluate interventions for the prevention and treatment of intestinal dysfunction in the study children. The successful control of intestinal diseases might result in a significant reduction in the morbidity and mortality associated with HIV infections in children and adults.