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EPIDEMIOLOGY OF FETAL DEATH AND PESTICIDE EXPOSURE

胎儿死亡和农药接触的流行病学

基本信息

批准号：
3251435
负责人：
James J beaumont
金额：
$ 7.77万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-07-01 至 1990-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3251435
关键词：
embryo /fetus death environmental toxicology epidemiology health surveys human pregnant subject human subject pesticides premature infant human questionnaires teratogens

项目摘要

The purpose of this proposal is to improve and expand an existing study of fetal death and pesticides exposure during pregnancy. There are a number of pesticides that are thought to have teratogenic/mutagenic potential, and these and other commonly used pesticides are being studied in the San Joaquin Valley of California where there is heavy use of pesticides. The epidemiologic study design is case-control, where cases are fatal deaths that have been identified from certificates of fetal death and controls are live births randomly chosen (within matching variable strata) from the same counties. There are 644 cases of fetal death and 644 control births. The specific aims are as follows: 1) increase the questionnaire response rate by means of phone calls and mailings (the response rate to date for subjects for whom we have good addresses is 55%), 2) locate study subjects who we have not been able to contact due to outdated addresses on certificates of birth and fetal death (24% of the study subjects), 3) geocode the residential addresses during pregnancy for linkage to pesticide application data for restricted pesticides, 4) develop computer algorithms for determining sections adjacent to place of residence for the pesticide linkage (a section is a square mile unit within township and range), 5) code data on medical, environmental, and other factors that were collected on the questionnaire, and 6) analyze the relationship of low birth weight and pesticide exposure within the control group of live births.

这项建议的目的是改善和扩大现有的研究胎儿死亡和怀孕期间接触农药。有很多杀虫剂被认为致畸/致突变潜力，以及这些和其他通常使用的杀虫剂正在研究在圣华金河谷，加州，那里大量使用杀虫剂。的流行病学研究设计是病例对照，其中病例是致命的从胎儿死亡证明中确认的死亡对照组是随机选择的活产（在匹配范围内不同的阶层）来自相同的县。有644例胎儿死亡和644例控制分娩。具体目标如下：1）增加调查问卷通过电话和邮件的回复率（回复率到目前为止，为谁，我们有良好的地址的主题是 55%），2）找到我们无法找到的研究对象由于出生证明上的地址已经过时，胎儿死亡（24%的研究对象），3）地理编码的住宅处理怀孕期间与农药施用的联系限制农药的数据，4）开发计算机算法，确定与居住地相邻的路段，农药联系（一个区是乡镇内的一个平方英里单位 5）关于医疗、环境和其他方面的编码数据问卷上收集的因素，和6）分析低出生体重与农药暴露关系活产的对照组。