Environmental Toxicology and Epidemiology Pre/Post Doctoral Research Training

 描述（由申请人提供） 环境毒理学和流行病学计划（ETEP）的目标是培养环境健康科学（EHS）的未来领导者，加速改善公共卫生。该计划的前提是，EHS的变革性研究需要具有专业知识的科学家从事多学科研究。 该计划重点关注人类疾病预防的转化应用，并提供连接环境机制毒理学（基础研究）和分子流行病学（基于人群的研究）的培训（即，T3转化研究）。 研究人员的重点是应用分子工具，如毒物暴露/反应的生物标志物，基因组学，表观基因组学，代谢组学，蛋白质组学和转录组学，在实验室模型和人群中进行机械导向的研究。拟议的培训继续他们非常成功的计划，进入我们的NIEHS支持的第32个年头。博士前学员专门从事环境流行病学或机械毒理学，并参加非专业领域的基础课程和高级课程（即，流行病学学员参加毒理学课程，反之亦然）。此外，还有一个共同的核心课程，包括生物信息学课程和专业交流与发展课程。研究者在本申请中申请8个博士前和3个博士后职位（0级、1级和2级），从上一周期的6个博士前奖学金增加到3个博士后奖学金。该培训补助金的受训人员支持的预期期限为两年，尽管博士前培训的预期总期限为4-5年。将鼓励博士前和博士后学员提交个人NRSA研究金申请（分别为F31或F32）。或者，也可以鼓励博士后学员提交K99/R 00申请。合格的申请人必须证明在EHS机械毒理学或机械导向的流行病学研究的职业动机。博士预科学员必须具有学士学位，并有相关的科学课程准备，并将被录取为博士。该计划在环境健康科学系，这在毒理学研究生培训的杰出历史。博士后研究员必须具有博士学位，医学博士，DVM或其他适当的博士学位。该计划涉及NIHES 2012-2017年战略计划的大部分主题和战略目标，旨在推进NIEHS的使命“发现环境如何影响人们，以促进更健康的生活”。"

 DESCRIPTION (provided by applicant) The objective of the Environmental Toxicology and Epidemiology Program (ETEP) is to train future leaders in environmental health sciences (EHS) who accelerate improvements in public health. This program is based on the premise that transformative research in EHS requires scientists with specialized knowledge who engage in multidisciplinary research. This program focuses on translational applications to human disease prevention with training that bridges environmental mechanistic toxicology (basic research) and molecular epidemiology (population-based research) (i.e., T3 translational research). The investigators' focus emphasizes the application of molecular tools such as biomarkers of toxicant exposure/response, genomics, epigenomics, metabolomics, proteomics, and transcriptomics to conduct mechanistically-oriented research in laboratory models and human populations. The proposed training continues their highly successful program, moving into our 32nd year of NIEHS support. Pre-doctoral trainees specialize in environmental epidemiology or mechanistic toxicology, and take a foundation course and an advanced course in the non-specialization area (i.e., epidemiology trainees take toxicology courses and vice versa). In addition, there is a common core curriculum that consists of a bioinformatics course and a course in professional communication and development. The investigators request 8 pre-doctoral and 3 postdoctoral positions (at levels 0, 1 and 2) in this submission, increased from 6 pre-doctoral fellowships and continuing 3 postdoctoral fellowships from the last cycle. The expected duration of trainee support on this training grant is two years, though the expected total duration of pre-doctoral training is 4-5 years. Pre-doctoral and postdoctoral trainees will be encouraged to submit Individual NRSA Fellowship applications (F31 or F32, respectively). Alternatively, postdoctoral trainees may be encouraged to submit K99/R00 application. Qualified applicants must demonstrate motivation for careers in EHS mechanistic toxicology or mechanistically-oriented epidemiology research. Pre-doctoral trainees must have a baccalaureate degree with relevant scientific coursework preparation and will be enrolled in a Ph.D. program in the Department of Environmental Health Sciences, which has a distinguished history of graduate training in toxicology. Postdoctoral fellows must have the Ph.D., M.D., DVM, or other appropriate doctoral degree. The program addresses most of the themes and strategic goals of the NIHES 2012-2017 Strategic Plan, and aims to advance the mission of the NIEHS "to discover how the environment affects people in order to promote healthier lives."