Elements of Bioremediation, Biomanufacturing & Bioenergy (E3B): Metals in Biology

生物修复、生物制造的要素

基本信息

批准号：
BB/S009787/1
负责人：
Nigel Robinson
金额：
$ 143.08万
依托单位：
Durham University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FS009787%2F1
关键词：
Elements Bioremediation Biomanufacturing Bioenergy E3B

项目摘要

The UK is well resourced with the multidisciplinary research skills needed to exploit metal-related biological processes in Biomanufacturing and in Bioenergy production. Demand for Metals in Biology expertise in these sectors is growing in concert with increased awareness (i) that more than a half of all Industrial Bioprocesses are likely to directly involve metalloproteins with most of the remainder being indirectly dependent upon metalloproteins, and (ii) that there is scope to increase competitiveness by optimising metalation and by tuning the catalytic activities of metal centres. This phase II E3B network will initiate new Academic-Industry collaborations in these sectors and encourage the migration of research and development instigated by the phase I Metals in Biology (MiB) BBSRC NIBB to higher technology readiness levels (TRLs). The phase I MiB BBSRC NIBB funded a dozen projects related to the Bioremediation and Biorecovery of valuable metals. The UK has considerable expertise in bioleaching and downstream metal recovery using bacterial, fungal and plant systems. For example, metal-reducing bacteria can be targeted to a wide range of high valence metals, with scope to precipitate them as valuable metallic nanoparticles with applications as catalysts, nanomagnets, targeted remediation agents (for metals and organics) and quantum dot materials. Bioremediation will therefore be a sector targeted by the phase II E3B network "but only where this leads to the recovery of valuable metals". A diversity of waste materials and waste streams will be targeted, industrial scale-up and process economics (including life cycle analysis) optimised. About a half of polluted sites in the UK that require remediation are contaminated with metals, or a combination of metals and organics. Bio-transformed bio-recovered metals (in catalytic nanoparticles or metalloenzymes) may also be used to remediate sites exclusively contaminated with organics, and a wide range of UK and international industries produce metal-contaminated effluents and residues. The E3B BBSRC NIBB will exploit this largely untapped resource.The network will run for 5 years and will take advantage of infrastructure, governance and experience gained under phase I MiB. These include (amongst others) the infrastructure to award and manage small grants and contacts (compliant with GDPR). The outcomes of phase I MiB (diversity of new collaborations, breadth and scale of membership, matching/other funding generated, jobs created or safeguarded, patents awarded, papers published, products launched) provide evidence of the ongoing potential for success of the E3B network and hence give a high degree of confidence that the E3B aims and objectives will be realised. Examples of 'potential' consortia to advance TRLs include:Improved hemylation and use of heme-enzymes to manufacture high-value products.The manufacture of vitamin B12 for industrial biotechnology and for sustainable nutrition.Bio-recovery of metals in high-value complexes from contaminated wastes.The free energies of intracellular metals for sustainable consumer goods manufacture.Intracellular availability of metals for quality control in the manufacture of biologics.Optimising trace metals in the manufacture of sources of bioenergy. Final reports show that almost all partnerships (> 90%) funded by MiB phase I are sustaining their Academic-Industry collaboration and/or are eager to find the means to do so, with many testimonials to this effect. For example, the Industrial partner of the final collaboration funded (October 2017) under MiB phase I wrote the following: "So far the development of the LPMOs has progressed very swiftly and we are excited to see the next steps in this project as it has a great potential." In common with most MiB phase I projects, this was a new Academic-Industry collaboration which E3B will progress to higher TRLs.

英国的资源丰富，具有利用与金属相关的生物制造和生物能源生产中与金属相关的生物过程所需的多学科研究技能。这些领域对生物学专业知识的金属需求的需求正在与提高的认识（i）一起增长（i），即超过一半的工业生物过程可能直接涉及金属蛋白，其余大多数是间接依赖金属蛋白的，并且（ii）通过调节金属和金属级别的金属活动来增强竞争力来增加范围，以提高范围。该第II阶段E3B网络将在这些领域启动新的学术行业合作，并鼓励生物学中I期金属（MIB）BBSRC NIBB煽动的研发迁移到更高的技术就绪水平（TRLS）。 I阶段MIB BBSRC NIBB资助了与生物修复和生物发现有关的十几个项目。英国在使用细菌，真菌和植物系统的生物渗入和下游金属回收方面具有丰富的专业知识。例如，还可以将富金属的细菌靶向多种高价金属，其范围将它们作为有价值的金属纳米颗粒作为催化剂，纳米磁铁，靶向修复剂（用于金属和有机物）和量子点材料的含量。因此，生物修复将是由II期E3B网络针对的部门“但仅在这导致有价值金属的回收率”。优化的工业规模和过程经济学（包括生命周期分析）将有针对性的各种废物和废物流。在英国，大约一半需要修复的污染地点被金属或金属和有机物的组合污染。生物转化的生物恢复金属（在催化纳米颗粒或冶金酶中）也可用于补救仅被有机物污染的部位，并且广泛的英国和国际工业生产金属污染金属污染的废水和残留物。 E3B BBSRC NIBB将利用这一尚未开发的资源。该网络将运行5年，并将利用在I期MIB下获得的基础设施，治理和经验。其中包括（除其他）基础设施授予和管理小型赠款和联系人（符合GDPR）。 I期MIB的结果（新合作的多样性，会员的广度和规模，匹配/其他资金，创建或保障的作业，授予专利，发布的论文，发布的产品）提供了持续的E3B网络成功潜力，因此可以使E3B AIM和目标具有很高的信心。推进TRL的“潜在”财团的示例包括：改善血红素和血红素酶制造高价值产品的使用。工业生物技术的维生素B12的生产和可持续营养的生产。Bio在高价值的货物中，用于污染的企业中的金属物质。在生物制剂生产中的质量控制金属的可用性。在生物能源来源生产中的痕量金属优化。最终报告显示，由MIB I期资助的几乎所有合作伙伴关系（> 90％）都在维持其学术行业合作和/或渴望找到这样做的手段，并有许多证词来实现这一影响。例如，在MIB阶段获得了最终合作的工业合作伙伴（2017年10月）写道：“到目前为止，LPMO的发展已经取得了非常迅速的进步，我们很高兴看到该项目的下一步，因为它具有很大的潜力。”与大多数MIB I期项目共同，这是一项新的学术行业合作，E3B将会发展为更高的TRL。