Metals in Biology: The elements of Biotechnology and Bioenergy

生物学中的金属：生物技术和生物能源的元素

• 批准号: BB/L013711/1
• 负责人: Nigel Robinson
• 金额: $ 92.37万
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL013711%2F1
• 关键词: Metals; Biology; elements; Biotechnology; Bioenergy

The purpose of this network is to make the UK the premier destination for research and development that demands Metals in Biology expertise. Metals catalyse the reactions of life and these demands are expected to grow.Some of the earliest discoveries, uncovering metals as vital components of proteins and not mere contaminants, were made in the UK. Today we have world leaders uncovering how cells handle metals and the mechanisms of metal-dependent enzymes. Now is an opportune moment to exploit this knowledge to the benefit of industry and society. UK businesses which will innovate with this knowledge include established world leaders in their sectors and new entrants. Metallo-proteins contribute to bio-energy production, bioremediation, biomedicine, synthesis of high value industrial feed-stocks and more. The metal-handling systems of cells are vital to sustain adequate metal-protein speciation in vivo. As nearly a half of enzymes, perhaps one third of all gene products, are estimated to require metals, the impact of this network will be pervasive.Metal-handling circuits can also be subverted to inhibit microbes. The exploitation of metals and metal-chelators as antimicrobials is a form of bio-mimicry since we are now starting to discover that immune systems manipulate metal-supply to inhibit microbial growth. Indeed, many common antibiotics tightly bind to metals and some antibiotics are closely related to iron-scavenging molecules (siderophores).Metal-supply pathways can be engineered for the manufacture of supplements such as cobalt-requiring vitamin B12 and enzymes with metallo-prosthetic groups. Talented individuals are currently scattered in different UK research communities. The efforts of biologists, chemists, mathematicians, engineers and others will be drawn together by this network to allow effective knowledge and skills transfer with industry and with the relevant regulatory authorities.The network will run for three years with structured workshops, a large community building meeting and additional ad hoc workshops throughout the tenure of the network.

该网络的目的是使英国成为需要Metals in Biology专业知识的研究和开发的首选目的地。金属催化生命的反应，这些需求预计还会增长。一些最早的发现是在英国完成的，发现金属是蛋白质的重要组成部分，而不仅仅是污染物。今天，我们有世界领先者揭示细胞如何处理金属和依赖金属的酶的机制。现在正是利用这一知识造福行业和社会的好时机。将利用这一知识进行创新的英国企业包括各自行业的老牌世界领先者和新进入者。金属蛋白在生物能源生产、生物修复、生物医学、合成高价值工业原料等方面做出了贡献。细胞的金属处理系统对维持体内足够的金属蛋白物种至关重要。据估计，近一半的酶，可能是所有基因产品的三分之一需要金属，因此这个网络的影响将是普遍的。金属处理电路也可以被颠覆，以抑制微生物。利用金属和金属螯合剂作为抗菌剂是一种生物模仿，因为我们现在开始发现，免疫系统操纵金属供应来抑制微生物生长。事实上，许多常见的抗生素与金属紧密结合，一些抗生素与铁清除分子(铁载体)密切相关。金属供应途径可以被设计用于制造补充剂，如需要钴的维生素B12和带有金属假体基团的酶。有才华的人目前分散在英国的不同研究社区。这个网络将把生物学家、化学家、数学家、工程师和其他人的努力凝聚在一起，以便与工业界和有关监管当局进行有效的知识和技能转移。该网络将运行三年，在整个网络任期内举行有组织的研讨会、大型社区建设会议和额外的特别研讨会。

项目成果

A tight tunable range for Ni(II) sensing and buffering in cells.

• DOI: 10.1038/nchembio.2310
• 发表时间: 2017-04
• 期刊: Nature chemical biology
• 影响因子: 14.8
• 作者: Foster AW;Pernil R;Patterson CJ;Scott AJP;Pålsson LO;Pal R;Cummins I;Chivers PT;Pohl E;Robinson NJ
• 通讯作者: Robinson NJ

The contribution of microbially produced nanoparticles to sustainable development goals.

• DOI: 10.1111/1751-7915.12788
• 发表时间: 2017-09
• 期刊: Microbial biotechnology
• 影响因子: 5.7
• 作者: Cueva ME;Horsfall LE
• 通讯作者: Horsfall LE

The coproporphyrin ferrochelatase of Staphylococcus aureus: mechanistic insights into a regulatory iron-binding site.

• DOI: 10.1042/bcj20170362
• 发表时间: 2017-10-10
• 期刊: The Biochemical journal
• 作者: Hobbs C;Reid JD;Shepherd M
• 通讯作者: Shepherd M

Impact of Solution Chemistry on the Biotechnological Synthesis and Properties of Palladium Nanoparticles : Palladium solution chemistry plays an important role in the bioreduction of Pd(II)

溶液化学对钯纳米粒子生物技术合成和性能的影响：钯溶液化学在 Pd(II) 的生物还原中发挥着重要作用

• DOI: 10.1595/205651323x16813753335431
• 发表时间: 2023
• 期刊: Johnson Matthey Technology Review
• 影响因子: 2.3
• 作者: Egan-Morriss C

Oxidative Diversification of Steroids by Nature-Inspired Scanning Glycine Mutagenesis of P450BM3 (CYP102A1)

• DOI: 10.1021/acscatal.0c02077
• 发表时间: 2020-08-07
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Chen, Wenyu;Fisher, Matthew J.;Wong, Luet L.
• 通讯作者: Wong, Luet L.