MECHANISMS OF VISUAL EXCITATION

视觉兴奋机制

• 批准号: 3258235
• 负责人: ALAN FEIN
• 金额: $ 22.51万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3258235
• 关键词: Urodela; bioenergetics; biological signal transduction; calcium; cellular respiration; cyclic GMP; electrophysiology; endoplasmic reticulum; eye pharmacology; fresh water environment; inositol; light adaptations; messenger RNA; mitochondria; photochemistry; prostaglandin receptor; retinal adaptation; rhodopsin; saltwater environment; visual photoreceptor; visual stimulus

The primary objective of this project is to elucidate the molecular basis of visual excitation and adaption and also to understand the mechanisms that regulate photoreceptor metabolism. The basic approach is to use electrophysiological and pharmacological techniques to study phototransduction and energy metabolism of individual photoreceptors. This work should yield important information about the normal working of these processes, which is an important prerequisite for understanding diseases that may involve the visual system.

本项目的主要目的是阐明分子机制