Mechanisms of Disease and Treatments in Novel Metabolic Development Brain Disorders
新型代谢发育脑疾病的疾病机制和治疗
基本信息
- 批准号:10622084
- 负责人:
- 金额:$ 2.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Administrative SupplementAwardBehaviorBiological AssayBrainBrain DiseasesChildDataData AnalysesDevelopmentDiseaseEnzymesFundingGeneticGlutamatesGrowthHealthHindlimbHistologyHumanInterventionKnockout MiceLaboratoriesLearningMammalian GeneticsManuscriptsMediatingMentorsMentorshipMetabolicMetabolic DiseasesMetabolismMicroscopyMitochondriaMotorMotor NeuronsNerve DegenerationNeuronsPatientsPhasePreparationPublic HealthPyruvateResearchResearch AssistantResearch TrainingScienceSpastic ParaplegiaTechniquesTrainingTransaminasesUnderrepresented PopulationsUnited States National Institutes of HealthUniversitiesWorkbasecareercareer developmentdietary restrictiondietary supplementsexperiencein vivointerestlensloss of function mutationmotor behaviornervous system disorderneurodevelopmentneurogeneticsnovelparent grantpostnatalpreclinical studyprogramssymposiumtreatment strategy
项目摘要
PROJECT SUMMARY
We have recently identified a novel human neurogenetic disorder caused by loss-of-function mutations in the
mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2). Genetic metabolic diseases, such as GPT2
disease, offer a powerful lens to investigate mechanisms of metabolism in human brain. Also, metabolic
diseases may be amenable to treatments via dietary restrictions or supplements. GPT2 disease involves
postnatal undergrowth of brain and progressive spastic paraplegia. Based on our extensive preliminary data, we
have established potential treatment strategies for GPT2 disease. To guide these interventions in children, we
are currently completing needed pre-clinical studies under the awarded parent grant “Mechanisms of disease
and treatment in novel metabolic developmental brain disorders 1R01NS121618-01A1”. This application
represents a request for supplemental funding to support the post-baccalaureate training of Mr. Kenneth Bradley.
Mr. Bradley is a recent Brown University graduate and will be a research assistant working on projects under the
scope of the parent grant within the Morrow Laboratory. Mr. Bradley will work primarily on training and
conducting studies related to Aim 1 of this project, since Mr. Bradley is specifically interested in neurogenetics
and motor behavior in neurodevelopmental and neurodegenerative conditions. Aim 1 is focused on in vivo
studies of Gpt2-mediated growth of motor neurons. Our Gpt2-null mouse recapitulates key aspects of disease,
such as hindlimb motor abnormalities, akin to spastic paraplegia seen in patients. This supplement outlines
research and training plans that will build-upon Mr. Bradley’s existing skillset, and that will dovetail with his
scientific interests going forward. In addition to learning mammalian genetics, neurodevelopment and the
laboratory techniques of histology, microscopy and behavior assays, Mr. Bradley will be provided with a
mentorship on career development from multiple mentors and supervisors, will attend a conference, and receive
training in data analysis and manuscript preparation. Taken together, these experiences will assist Mr. Bradley
as he prepares for the next phase of his career in the biomedical workforce.
Page 41 of 55
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric M Morrow其他文献
Postictal psychosis: presymptomatic risk factors and the need for further investigation of genetics and pharmacotherapy
- DOI:
10.1186/1744-859x-5-9 - 发表时间:
2006-07-21 - 期刊:
- 影响因子:3.100
- 作者:
Eric M Morrow;Jennifer M Lafayette;Edward B Bromfield;Gregory Fricchione - 通讯作者:
Gregory Fricchione
Eric M Morrow的其他文献
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{{ truncateString('Eric M Morrow', 18)}}的其他基金
Mechanisms of disease and treatment in novel metabolic developmental brain disorders
新型代谢性发育性脑疾病的疾病机制和治疗
- 批准号:
10375639 - 财政年份:2021
- 资助金额:
$ 2.8万 - 项目类别:
Mechanisms of Disease and Treatment in Novel Metabolic Developmental Brain Disorders
新型代谢性发育性脑疾病的疾病机制和治疗
- 批准号:
10527375 - 财政年份:2021
- 资助金额:
$ 2.8万 - 项目类别:
Mechanisms of disease and treatment in novel metabolic developmental brain disorders
新型代谢性发育性脑疾病的疾病机制和治疗
- 批准号:
10712302 - 财政年份:2021
- 资助金额:
$ 2.8万 - 项目类别:
Mechanisms of Disease and Treatment in Novel Metabolic Developmental Brain Disorders
新型代谢性发育性脑疾病的疾病机制和治疗
- 批准号:
10745757 - 财政年份:2021
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative mechanisms in Christianson syndrome and NHE6-related disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
9811045 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative Mechanisms in Christianson Syndrome and NHE6-Related Disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
10417212 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative mechanisms in Christianson syndrome and NHE6-related disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
10020810 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative Mechanisms in Christianson Syndrome and NHE6-Related Disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
10653694 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative Mechanisms in Christianson Syndrome and NHE6-Related Disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
10213154 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
Neurodegenerative mechanisms in Christianson syndrome and NHE6-related disorders
Christianson 综合征和 NHE6 相关疾病的神经退行性机制
- 批准号:
10164658 - 财政年份:2019
- 资助金额:
$ 2.8万 - 项目类别:
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