课题基金 / 基金详情

Drivers and dynamics of antimicrobial resistance and Salmonella in Brazilian pig and poultry production

Drivers and dynamics of antimicrobial resistance and Salmonella in Brazilian pig and poultry production
巴西生猪和家禽生产中抗生素耐药性和沙门氏菌的驱动因素和动态
批准号:
BB/S018913/1
负责人:
Alison Mather
金额:
$40.13万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2019
资助国家:
英国
项目状态:
已结题
起止时间:
2019 至 --

项目摘要

项目成果

Alison Mather的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Antimicrobial resistance (AMR) of bacteria found in livestock represent a grave threat to the health of both animals and humans; resistant infections in livestock also have a significant economic impact. Salmonella enterica is one of the most important bacterial pathogens in pigs and poultry, which are thought to be two of the major reservoirs for human infections. Brazil is one of the world's largest producers and exporters of pig and chicken meat, and these industries are significant contributors to the country's economy. Change in these production systems over the last 10-15 years, including massive intensification and introduction of a Salmonella Enteritidis vaccine in poultry, have led to dramatic shifts in the Salmonella serotype prevalence observed from pigs and poultry in Brazil. These shifts are probably driven by antimicrobial use and resistance, but this issue has not been fully investigated.The research outlined in our proposal builds on our one-year pump-priming grant investigating the diversity and evolution of AMR determinants in Salmonella isolated from Brazilian pigs and poultry over the last 10 years. In the course of our work, we will dramatically increase the number of available Salmonella genome sequences from Brazilian livestock; by doing so, we can identify where they fit in the global context and identify when specific subtypes emerged in Brazil. We will also look at the genetic determinants, such as AMR, facilitating the persistence of Salmonella through the food chain. By investigating the changes in AMR and serotype over the life course of livestock animals, we will help inform potential vaccine strategies. Finally, by examining AMR in the gut co-resident non-pathogenic bacteria in livestock and correlating total resistance with antimicrobial usage, we will ascertain their potential role as a reservoir of AMR genes for pathogenic bacteria such as Salmonella, as AMR genes can move between bacteria through horizontal gene transfer. We will achieve these aims using whole genome sequencing, state-of-the-art long read sequencing, combined with molecular biology and epidemiology. This proposal exploits the effective and productive collaboration between Dr Alison Mather and Dr Justin O'Grady at Quadram Institute Bioscience (QIB) in the UK, and Dr Andrea Moreno, Dr Terezinha Knöbl and Dr Luisa Moreno at the University of São Paulo (USP), along with collaborators Dr Emma Doughty at QIB and Dr Liljana Petrovska at the Animal and Plant Health Agency. Antimicrobial consumption in livestock is expected to nearly double in Brazil by 2030; this research will tackle the huge health and economic threat posed by AMR to Brazilian livestock species, which will help identify where suitable control strategies could be applied most effectively.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI: 10.3390/pathogens11030358
发表时间: 2022-03-16
期刊: Pathogens (Basel, Switzerland)
影响因子: --
作者: [Gomes VTM, Moreno LZ, Silva APS, Thakur S, La Ragione RM, Mather AE, Moreno AM]
通讯作者: Moreno AM
MEtaGenome-informed Antimicrobial resistance Surveillance: Harnessing long-read sequencing for an analytical, indicator and risk assessment framework
  • 批准号:
    MR/Y034457/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $46.69万
  • 财政年份:
    2024
  • 负责人:
    Alison Mather
  • 依托单位:
Canada IPAP: Evolutionary dynamics of antimicrobial resistance in human impacted soils: does the genie go back into the bottle?
  • 批准号:
    BB/X012719/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $19.08万
  • 财政年份:
    2023
  • 负责人:
    Alison Mather
  • 依托单位:
Brazil Partnering Award: "Microbial genomics approaches to improve farm animal health and food safety"
  • 批准号:
    BB/W018713/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $5.59万
  • 财政年份:
    2022
  • 负责人:
    Alison Mather
  • 依托单位:
Canada Partnering Award: "Development of Genomic Approaches to Antimicrobial Resistance in a One Health Framework"
  • 批准号:
    BB/T020199/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $6.5万
  • 财政年份:
    2022
  • 负责人:
    Alison Mather
  • 依托单位:
国内基金
海外基金
发展基因编码的荧光探针揭示趋化因子CXCL10的时空动态及其调控机制
β-arrestin2- MFN2-Mitochondrial Dynamics轴调控星形胶质细胞功能对抑郁症进程的影响及机制研究
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2023
  • 负责人:
  • 依托单位:
用于对微管动态结构实时定量分析的荧光探针
  • 批准号:
    32070708
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    谢松波
  • 依托单位:
钱江潮汐影响下越江盾构开挖面动态泥膜形成机理及压力控制技术研究
  • 批准号:
    LY21E080004
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2020
  • 负责人:
    尹鑫晟
  • 依托单位: