VESTIBULAR SYSTEM ACTIVATION DURING PITCH WHILE ROTATING

改变头部相对于重力的方向会导致 在眼球代偿运动的戏剧性变化所产生的 前庭系统 围绕垂直轴倾斜的旋转导致 持续性眼震，只要刺激持续并取消 旋转停止时的旋转后反应。 类似的效果 在绕垂直线旋转的同时来回俯仰头部而产生的 轴（Raphan等人，1981年）。 这项研究的目的是描述 俯仰诱发眼球震颤慢相速度的动力学 并将其与绕着一个 偏离垂直轴 具体来说，我们将确定 响应，饱和速度，以及与 动物停止时的旋转后反应。 这应该能让我们 为了阐明从迷宫到速度的耦合的性质， 一种存储机制或集成器，似乎是生成 前庭和视觉系统的眼球震颤。 细胞外 单位活动将记录在前庭神经和前庭 原子核。 慢相眼速度和单位活动将在 时域和频域，使用已经设计的计算机程序 最近 眼动和单位数据将进行比较，以确定是否 眼速度的变化准确地反映了单位活动的变化。 这 关系将与我们的模型预测的 组织产生前庭慢相速度的系统， 视动性眼球震颤 这一刺激的一个特别有趣的特点是 它与迷宫的所有部分都接合，根据我们的研究， 预测，每个部分的贡献是必要的，以生成 准确的补偿眼速度。 这项研究将提供更多 深入了解垂直和水平半规管以及 耳石与前庭神经核和眼神经核通过 速度存储机制来产生眼球震颤。

Changing the orientation of the head with regard to gravity causes a dramatic change in ocular compensatory movements generated by the vestibular system. Rotation about axes titled from the vertical causes continuous nystagmus for as long as the stimulus persists and cancels the post-rotatory response when the rotation stops. A similar effect is produced by pitching the head to and fro while rotating about a vertical axis (Raphan et al., 1981). The aim of this research is to characterize the dynamics of the slow phase velocity of nystagmus induced by pitching during rotation and to compare it to that induced by rotation about an off-vertical axis. Specifically we will determine the gain of the response, the saturation velocity, and the interaction with the post-rotatory response when the animal is stopped. This should enable us to elucidate the nature of the coupling from the labyrinth to the velocity storage mechanism or integrator that appears to be a focus for generating nystagmus from the vestibular as well as the visual system. Extracellular unit activity will be recorded in the vestibular nerve and the vestibular nuclei. Slow phase eye velocity and unit activity will be analyzed in the time and frequency domains using computer programs which have been devised recently. Eye movement and unit data will be compared to determine if changes in eye velocity accuragely reflect changes in unit activity. This relationship will be compared to that kpredicted by our model of the organization of the system generating slow phase velocity of vestibular and optoinetic nystagmus. A particularly interesting feature of this stimulus is that it engages all parts of the labyrinth, and according to our predictions, a contribution from each part is necessary to generate accurate compensatory eye velocities. This research should give greater insight into how the vertical and horizontal semicircular canals as well as the otoliths couple to the vestibular nuclei and oculomotor nuclei through the velocity storage mechanism to generate nystagmus.