VESTIBULAR SYSTEM ACTIVATION DURING PITCH WHILE ROTATING

改变头部相对于重力的方向会导致 眼球代偿性运动的戏剧性变化 前庭系统。绕垂直起因倾斜的轴旋转 只要刺激持续，就会持续眼震，并取消 旋转停止时的旋转后响应。类似的效果是 通过在围绕垂直方向旋转的同时使头部来回倾斜而产生的 Axis(Raphan等人，1981年)。这项研究的目的是描述 俯仰诱发眼球震颤的慢相速度动力学 并将其与围绕 偏离垂直轴。具体地说，我们将确定 响应、饱和速度以及与 动物停止时的旋转后反应。这应该能让我们 阐明迷宫与速度耦合的本质 存储机构或积分器，似乎是生成的焦点 前庭和视觉系统的眼球震颤。胞外 单位活动将被记录在前庭神经和前庭 原子核。慢相眼球速度和单位活动将在 使用已经设计的计算机程序的时间和频率域 最近。将比较眼动和单位数据，以确定是否 眼速的变化准确地反映了单位活动的变化。这 关系将与我们的模型预测的k值进行比较 产生前庭和前庭慢相速度的系统的组织 视动性眼球震颤。这一刺激计划的一个特别有趣的特点 它占用了迷宫的所有部分，根据我们的说法 预测，每个部分都需要贡献才能生成 准确的补偿眼球速度。这项研究应该给出更大的 洞察垂直和水平半规管以及 耳石通过与前庭神经核和动眼神经核相连。 产生眼球震颤的速度储存机制。

Changing the orientation of the head with regard to gravity causes a dramatic change in ocular compensatory movements generated by the vestibular system. Rotation about axes titled from the vertical causes continuous nystagmus for as long as the stimulus persists and cancels the post-rotatory response when the rotation stops. A similar effect is produced by pitching the head to and fro while rotating about a vertical axis (Raphan et al., 1981). The aim of this research is to characterize the dynamics of the slow phase velocity of nystagmus induced by pitching during rotation and to compare it to that induced by rotation about an off-vertical axis. Specifically we will determine the gain of the response, the saturation velocity, and the interaction with the post-rotatory response when the animal is stopped. This should enable us to elucidate the nature of the coupling from the labyrinth to the velocity storage mechanism or integrator that appears to be a focus for generating nystagmus from the vestibular as well as the visual system. Extracellular unit activity will be recorded in the vestibular nerve and the vestibular nuclei. Slow phase eye velocity and unit activity will be analyzed in the time and frequency domains using computer programs which have been devised recently. Eye movement and unit data will be compared to determine if changes in eye velocity accuragely reflect changes in unit activity. This relationship will be compared to that kpredicted by our model of the organization of the system generating slow phase velocity of vestibular and optoinetic nystagmus. A particularly interesting feature of this stimulus is that it engages all parts of the labyrinth, and according to our predictions, a contribution from each part is necessary to generate accurate compensatory eye velocities. This research should give greater insight into how the vertical and horizontal semicircular canals as well as the otoliths couple to the vestibular nuclei and oculomotor nuclei through the velocity storage mechanism to generate nystagmus.