CHILD VISION SCREENING--CASE CONTROL MODALITY COMPARISON

用于筛查斜视和斜视的最佳方法是什么？ 弱视？ 大多数关于这个问题的研究只使用了一个测试 模态，少数多模态比较研究具有重要意义 限制。本提案是一项流行病学病例对照研究 比较几种筛选测试方式。精心优化的版本 所使用的测试被合并，以证明每种模式的完整 潜力。所选择的方式似乎最有希望实现实际应用 筛查应用：线性斯内伦等效视力，各向同性 光折射、离轴光折射和随机点立体图 测试。所有四种模式都将在蒙面测试中对每个受试者进行测试 协议，包括全面的眼科检查，还包括 随机交错匹配的正常人群和选择的患者 代表了从严重到轻微的斜视、弱视和 弱视性屈光缺陷。研究人群为 3 至 4 岁，他们： (a) 年龄足以进行主观感官测试，并且 避免婴儿测试的变异性增加； (b) 足够年轻 仍然属于发育可塑性区间，神经和 解剖学上；以及谁 (c) 本身构成筛查目标 人口。该研究的目标是确定哪种测试方式， 或者需要哪种方式组合来检测斜视、弱视、 和弱视屈光缺陷，具有最佳灵敏度和 特异性。

What is the best method, or methods, to use in screening for strabismus and amblyopia? Most studies of the matter have used only a single test modality, and the few multi-modality comparison studies have had important limitations. The present proposal is an epidemiologic case control study comparing several screening test modalities. Carefully optimized versions of the tests used are incorporated, to demonstrate each modality's full potential. The modalities chosen seem most promising for practical screening application: Linear Snellen-equivalent visual acuity, isotropic photorefraction, off-axis photorefraction, and random dot stereogram testing. All four modalities will be tested on each subject in a masked protocol, with a full ophthalmological examination, also will consist of randomly interleaved matched populations of normals, and patients chosen to represent a full spectrum of major to minor strabismic, amblyopic and amblyopiagenic refractive deficits. The study population will be 3 to 4 year-olds, who are: (a) old enough to allow subjective sensory testing and to avoid the increased variability of infant testing; (b) young enough to still fall within the developmental plasticity interval, neurally and anatomically; and who (c) themselves constitute a screening target population. The goal of the study will be to determine which test modality, or which modality combination, is required to detect strabismic, amblyopic, and amblyopiagenic refractive deficits with optimal sensitivity and specificity.