CHILD VISION SCREENING--CASE CONTROL MODALITY COMPARISON

筛查斜视和斜视的最佳方法是什么？ 弱视？大多数关于这一问题的研究都只使用了一种测试 情态，少数几个多情态比较研究具有重要的意义 限制。本研究为流行病学病例对照研究。 比较几种筛查试验模式。精心优化的版本 所使用的测试的一部分被合并，以展示每种模式的完整 潜力。所选择的模式似乎是最有希望的实用方法 筛查应用：线性Snellen等效视敏度，各向同性 光折变、离轴光折变和随机点立体图 测试。所有四种模式都将在每个受试者身上戴着面具进行测试 协议，以及全面的眼科检查，也将包括 随机交叉匹配的正常人群和被选为 代表了从严重到轻微的斜视、弱视和 弱视引起的屈光不正。研究人群将为3至4人 以避免婴儿测试的变异性增加；(B)足够年轻到 仍在发育可塑性区间内，神经和 以及(C)本身构成筛查目标的人 人口。这项研究的目标将是确定哪种测试模式， 或者需要哪种模式组合来检测斜视、弱视 和弱视性屈光不全，具有最佳的敏感度和 专一性。

What is the best method, or methods, to use in screening for strabismus and amblyopia? Most studies of the matter have used only a single test modality, and the few multi-modality comparison studies have had important limitations. The present proposal is an epidemiologic case control study comparing several screening test modalities. Carefully optimized versions of the tests used are incorporated, to demonstrate each modality's full potential. The modalities chosen seem most promising for practical screening application: Linear Snellen-equivalent visual acuity, isotropic photorefraction, off-axis photorefraction, and random dot stereogram testing. All four modalities will be tested on each subject in a masked protocol, with a full ophthalmological examination, also will consist of randomly interleaved matched populations of normals, and patients chosen to represent a full spectrum of major to minor strabismic, amblyopic and amblyopiagenic refractive deficits. The study population will be 3 to 4 year-olds, who are: (a) old enough to allow subjective sensory testing and to avoid the increased variability of infant testing; (b) young enough to still fall within the developmental plasticity interval, neurally and anatomically; and who (c) themselves constitute a screening target population. The goal of the study will be to determine which test modality, or which modality combination, is required to detect strabismic, amblyopic, and amblyopiagenic refractive deficits with optimal sensitivity and specificity.