PROSPECTIVE STUDY OF ESOTROPIS DEVELOPMENT

内斜发育的前瞻性研究

• 批准号: 3264609
• 负责人: KURT SIMONS
• 金额: $ 17.32万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3264609
• 关键词: amblyopia; binocular vision; disease /disorder prevention /control; disease /disorder proneness /risk; eye coordination disorder; eye disorder diagnosis; eye movements; human subject; infant human (0-1 year); longitudinal human study; prognosis; vision tests; visual threshold; visual tracking

Can the binocular vision prognosis in infantile esotropia be improved beyond the monofixation or worse outcome typically achieved with current detection and treatment methods? Can manifestation of the deviation be prevented to begin with? The present (revised) proposal will investigate the hypothesis that there are "precursor" sensory and/or oculomotor states prior to the onset of infantile esotropia which may provide the basis for affirmative answers to these questions.l The proposed study will be longitudinal in design, comprised of initial binocular vision, motor and refractive measurements in at least 825 4 to 24 week old infants at normal or high risk for esotropia, and then follow-up one and two years later to determine if esotropia has developed. Our hypothesis is that there will be a difference in one or a combination of the early measures between the population of infants who develop esotropia and those who do not. Binocular vision tests include measurement of peripheral fusion by dynamic random dot "fusiogram" or "aniseikoniagram," and stereoacuity by dynamic random dot stereogram. Eye movements will be the response measure, and eye tracking records will also be analyzed for oculomotor anomalies that may themselves constitute esotropia precursors. All study participants will receive a full clinical examination, including cycloplegic retinoscopy.

婴幼儿内斜视的双眼视力预后能否得到改善