CHILD VISION SCREENING--CASE CONTROL MODALITY COMPARISON

儿童视力筛查--病例对照方式比较

• 批准号: 3265088
• 负责人: KURT SIMONS
• 金额: $ 22.67万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265088
• 关键词: amblyopia; diagnosis quality /standard; eye refraction disorder; human subject; pediatrics; preschool child (1-5); vision tests

What is the best method, or methods, to use in screening for strabismus and amblyopia? Most studies of the matter have used only a single test modality, and the few multi-modality comparison studies have had important limitations. The present proposal is an epidemiologic case control study comparing several screening test modalities. Carefully optimized versions of the tests used are incorporated, to demonstrate each modality's full potential. The modalities chosen seem most promising for practical screening application: Linear Snellen-equivalent visual acuity, isotropic photorefraction, off-axis photorefraction, and random dot stereogram testing. All four modalities will be tested on each subject in a masked protocol, with a full ophthalmological examination, also will consist of randomly interleaved matched populations of normals, and patients chosen to represent a full spectrum of major to minor strabismic, amblyopic and amblyopiagenic refractive deficits. The study population will be 3 to 4 year-olds, who are: (a) old enough to allow subjective sensory testing and to avoid the increased variability of infant testing; (b) young enough to still fall within the developmental plasticity interval, neurally and anatomically; and who (c) themselves constitute a screening target population. The goal of the study will be to determine which test modality, or which modality combination, is required to detect strabismic, amblyopic, and amblyopiagenic refractive deficits with optimal sensitivity and specificity.

什么是最好的方法，或方法，用于筛选斜视和 弱视？ 大多数关于这一问题的研究只使用了一种测试方法 模态，以及少数多模态比较研究具有重要意义 局限性。本研究为流行病学病例对照研究 比较几种筛查方法精心优化的版本 所使用的测试被纳入，以证明每种模式的完整性， 潜力所选择的模式似乎最有希望用于实际的 筛查应用：线性Snellen等效视力，各向同性 摄影验光、离轴摄影验光和随机点立体图 试验.所有四种模式将在设盲的 方案包括全面眼科检查，还包括 随机交错匹配的正常人群，和患者选择， 代表了从大到小的斜视、弱视和 弱视性屈光缺陷研究人群为3至4人 年龄：（a）足够大，可以进行主观感觉测试， 避免婴儿测试的可变性增加;（B）足够年轻， 仍然属于发育可塑性区间，神经和 （c）本身构成筛选目标 人口本研究的目标是确定哪种测试模式， 或者需要哪种模态组合来检测斜视，弱视， 和具有最佳灵敏度的弱视性屈光缺陷， 的特异性