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PROSPECTIVE STUDY OF ESOTROPIS DEVELOPMENT

内斜发育的前瞻性研究

基本信息

批准号：
2161591
负责人：
KURT SIMONS
金额：
$ 3.22万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-04-01 至 1996-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2161591
关键词：
amblyopia binocular vision disease /disorder prevention /control disease /disorder proneness /risk eye coordination disorder eye disorder diagnosis eye movements human subject infant human (0-1 year) longitudinal human study prognosis vision tests visual threshold visual tracking

项目摘要

Can the binocular vision prognosis in infantile esotropia be improved beyond the monofixation or worse outcome typically achieved with current detection and treatment methods? Can manifestation of the deviation be prevented to begin with? The present (revised) proposal will investigate the hypothesis that there are "precursor" sensory and/or oculomotor states prior to the onset of infantile esotropia which may provide the basis for affirmative answers to these questions.l The proposed study will be longitudinal in design, comprised of initial binocular vision, motor and refractive measurements in at least 825 4 to 24 week old infants at normal or high risk for esotropia, and then follow-up one and two years later to determine if esotropia has developed. Our hypothesis is that there will be a difference in one or a combination of the early measures between the population of infants who develop esotropia and those who do not. Binocular vision tests include measurement of peripheral fusion by dynamic random dot "fusiogram" or "aniseikoniagram," and stereoacuity by dynamic random dot stereogram. Eye movements will be the response measure, and eye tracking records will also be analyzed for oculomotor anomalies that may themselves constitute esotropia precursors. All study participants will receive a full clinical examination, including cycloplegic retinoscopy.

婴儿内斜视的双眼视力预后能否改善超出当前通常实现的单一固定或更糟糕的结果检测和治疗方法？偏差的表现形式可以是一开始就被阻止了？目前（修订后）的提案将调查存在“前体”感觉和/或动眼神经状态的假设在婴儿内斜视发生之前，这可能为对这些问题的回答都是肯定的。拟议的研究将是纵向设计，包括初步至少 825 4 至 24 进行双眼视觉、运动和屈光测量内斜视正常或高风险的周龄婴儿，然后随访一年和两年后确定是否出现内斜视。我们的假设是，其中一个或多个因素的组合会存在差异患有内斜视的婴儿群体之间的早期措施以及那些不这样做的人。双眼视觉测试包括通过动态测量周围融合随机点“fusiogram”或“aniseikoniagram”，以及动态立体视觉随机点立体图。眼球运动将作为反应测量，并且眼睛还将分析跟踪记录以发现可能出现的动眼神经异常情况。它们本身就构成了内斜视的前兆。所有研究参与者都将接受全面的临床检查，包括散瞳检影检查。