PROSPECTIVE STUDY OF ESOTROPIS DEVELOPMENT

内斜发育的前瞻性研究

• 批准号: 3264608
• 负责人: KURT SIMONS
• 金额: $ 16.75万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3264608
• 关键词: amblyopia; binocular vision; disease /disorder prevention /control; disease /disorder proneness /risk; eye coordination disorder; eye disorder diagnosis; eye movements; human subject; infant human (0-1 year); longitudinal human study; prognosis; vision tests; visual threshold; visual tracking

Can the binocular vision prognosis in infantile esotropia be improved beyond the monofixation or worse outcome typically achieved with current detection and treatment methods? Can manifestation of the deviation be prevented to begin with? The present (revised) proposal will investigate the hypothesis that there are "precursor" sensory and/or oculomotor states prior to the onset of infantile esotropia which may provide the basis for affirmative answers to these questions.l The proposed study will be longitudinal in design, comprised of initial binocular vision, motor and refractive measurements in at least 825 4 to 24 week old infants at normal or high risk for esotropia, and then follow-up one and two years later to determine if esotropia has developed. Our hypothesis is that there will be a difference in one or a combination of the early measures between the population of infants who develop esotropia and those who do not. Binocular vision tests include measurement of peripheral fusion by dynamic random dot "fusiogram" or "aniseikoniagram," and stereoacuity by dynamic random dot stereogram. Eye movements will be the response measure, and eye tracking records will also be analyzed for oculomotor anomalies that may themselves constitute esotropia precursors. All study participants will receive a full clinical examination, including cycloplegic retinoscopy.

婴儿内斜视的双眼视觉预后能否得到改善 超过了当前器械通常达到的单一固定或更差结局 检测和治疗方法？ 偏差的表现是否可以 一开始就被阻止了吗 本（修订）提案将调查 假设存在“前体”感觉和/或视觉状态， 在婴儿内斜视发作之前，这可能为 对这些问题的肯定回答。 拟议的研究将是纵向设计，包括最初的 双眼视觉、运动和屈光测量至少825 4至24 正常或内斜视高风险的1周大婴儿，然后随访 一年和两年后，以确定是否有内斜视发展。 我们 一个假设是，在以下一个或多个方面存在差异 儿童内斜视的早期测量 和那些没有的人 双眼视觉测试包括通过动态测量周边融合， 随机点“融合图”或“不等像图”，以及动态立体视敏度 随机点立体图 眼动将是反应措施， 还将分析跟踪记录中的眼部异常， 它们本身构成内斜视的前体。 所有研究参与者将接受全面的临床检查，包括 睫状肌麻痹视网膜检影法