SPATIAL FREQUENCY ANALYSIS OF RETINA W-CELLS

视网膜 W 细胞的空间频率分析

• 批准号: 3265148
• 负责人: MICHAEL H ROWE
• 金额: $ 10.03万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265148
• 关键词: cats; eye disorder chemotherapy; eye disorder diagnosis; neural information processing; retinal ganglion; synapses; visual fields; visual perception

The mammalian retinal ganglion cell population comprises a number of functionally distinct groups of neuronrther been shown to be anatomically segregated as they course through the optic tract. In cats, a heterogeneous mixture of ganglion cells, often collectively referred to as W-cells, make up about 50% of the total population. Nevertheless, their receptive field properties have not been thoroughly analyzed and are not fully undestood. Consequently, we have littel understanding of their role in visual information processing, and are not yet able to explore the mechanisms underlying their response characteristics. Such knowledge is vital, however, in order to fully understand how various retinal perception, and will be important for the development of effective diagnostic and thereapeutic procedures. This proposal is to do a thorough and quantitative analysis of he receptive field components of W-cells in the cat retina in vivo, using the method of spatial frequency analysis. Specifically, these experiments will: (1) identify and characterize the receptive field components of retinal W-cells in terms which will allow direct comparisons with X- and Y-cells; (2) make it possible to analyze the complex visual behavior of these cells in terms of interactions amng well defined receptive field components; (3) provide a basis for understanding the role of W-cells in visual information processing and visual perception; (4) provide a basis for exploring the cellular and synaptic mechanisms underlying receptive field formation in W-cells.

哺乳动物视网膜神经节细胞群包含许多 功能不同的神经元组的功能也被证明是 在解剖学上是分开的 在猫中，神经节细胞的异质混合物，通常 统称为W细胞，占总数的50%左右 人口 然而，它们的感受野特性 没有被彻底分析，也没有被完全理解。 因此，我们对它们在视觉中的作用了解甚少。 信息处理，还不能探索 其反应特征的潜在机制。 等 然而，知识是至关重要的，以便充分了解如何 各种视网膜知觉，并将是重要的 制定有效的诊断和治疗程序。 本文拟对这一问题进行深入的定量分析， 体内猫视网膜中W细胞的感受野成分， 采用空间频率分析方法。 具体地说， 这些实验将：（1）识别和表征 视网膜W细胞的感受野成分， 允许与X细胞和Y细胞直接比较;（2）使其成为可能 来分析这些细胞的复杂视觉行为， 相互作用amng明确定义的感受野组件;（3） 为理解W细胞在视觉中的作用提供了基础。 信息处理和视觉感知;（4）提供基础 用于探索潜在的细胞和突触机制 W细胞感受野的形成。