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RETINAL INPUTS TO VISUAL CORTEX

视网膜对视觉皮层的输入

基本信息

批准号：
2444368
负责人：
MICHAEL H ROWE
金额：
$ 17.7万
依托单位：
OHIO UNIVERSITY ATHENS
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-07-01 至 1999-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2444368
关键词：
action potentials brain electrical activity brain mapping cats neural information processing neurophysiology retinal ganglion visual cortex visual fields visual pathways

项目摘要

In spite of several decades of intensive study, many prominent features of the physiology of visual cortex have not been fully elucidated. Among these are 1) the precise mapping of different retinal ganglion cell classes onto the diversity of cortical areas, layers and cell types, and 2) the mechanisms by which retinal signals are converge onto cortical cells so as to produce emergent properties such as orientation selectivity. In this proposal, we present a new method which permits direct exploration of these and other issues. We plan to record simultaneously from cortical cells and retinal ganglion cells with overlapping receptive fields, and by means of cross-correlating their spike trains, to identify the specific retinal inputs to cortical cells. By systematically mapping multiple retinal inputs to single cortical cells, we can test hypotheses about the contributions that these inputs make to cortical cell receptive field structure and properties. We can also compare the spatial and temporal tuning characteristics of cortical cells with that of their inputs, and can identify the contributions that X, Y, and W cells make to the functional attributes of cortical areas 17, 18, and 19 and their constituent cell types. These results will greatly expand our understanding of information processing in the visual system, and will establish a foundation upon which to understand the functions of intrinsic cortical circuits.

尽管经过几十年的深入研究，视觉皮层的生理学尚未完全阐明。之间这些是1）不同视网膜神经节细胞的精确映射分类到皮层区域、层和细胞类型的多样性， 2)视网膜信号汇聚到皮层的机制细胞，以产生涌现的属性，选择性在这个建议中，我们提出了一种新的方法，直接探讨这些问题和其他问题。我们计划录制同时从皮质细胞和视网膜神经节细胞，重叠的感受野，并通过互相关， spike trains，以识别特定的视网膜皮层细胞的输入。通过系统地将多个视网膜输入映射到单个皮质细胞，我们可以测试关于这些输入的贡献的假设使皮层细胞感受野的结构和性质。我们可以还比较了皮层的空间和时间调谐特性，细胞与他们的输入，并可以确定的贡献， X、Y和W细胞对皮质区17的功能属性的影响， 18和19及其组成细胞类型。这些成果将大大扩展我们对视觉系统中信息处理的理解，并将建立一个基础，在此基础上了解的功能，内在皮层回路