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SPATIAL FREQUENCY ANALYSIS OF RETINA W-CELLS

视网膜 W 细胞的空间频率分析

基本信息

批准号：
3265152
负责人：
MICHAEL H ROWE
金额：
$ 8.67万
依托单位：
OHIO UNIVERSITY ATHENS
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-04-01 至 1993-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3265152
关键词：
cats eye disorder chemotherapy eye disorder diagnosis neural information processing retinal ganglion synapses visual fields visual perception

项目摘要

The mammalian retinal ganglion cell population comprises a number of functionally distinct groups of neuronrther been shown to be anatomically segregated as they course through the optic tract. In cats, a heterogeneous mixture of ganglion cells, often collectively referred to as W-cells, make up about 50% of the total population. Nevertheless, their receptive field properties have not been thoroughly analyzed and are not fully undestood. Consequently, we have littel understanding of their role in visual information processing, and are not yet able to explore the mechanisms underlying their response characteristics. Such knowledge is vital, however, in order to fully understand how various retinal perception, and will be important for the development of effective diagnostic and thereapeutic procedures. This proposal is to do a thorough and quantitative analysis of he receptive field components of W-cells in the cat retina in vivo, using the method of spatial frequency analysis. Specifically, these experiments will: (1) identify and characterize the receptive field components of retinal W-cells in terms which will allow direct comparisons with X- and Y-cells; (2) make it possible to analyze the complex visual behavior of these cells in terms of interactions amng well defined receptive field components; (3) provide a basis for understanding the role of W-cells in visual information processing and visual perception; (4) provide a basis for exploring the cellular and synaptic mechanisms underlying receptive field formation in W-cells.

哺乳动物视网膜神经节细胞群由多个在功能上不同的神经元组被证明是当它们穿过视束时在解剖上是分开的。猫的神经节细胞的异质混合体，通常统称为W细胞，约占总数的50% 人口。然而，它们的接受场属性具有没有得到彻底的分析，也不是完全不确定。因此，我们对它们在视觉上的作用知之甚少信息处理，并且还不能探索他们的反应特征背后的机制。是这样的然而，知识是至关重要的，以便充分理解各种视网膜感知，并将是重要的制定有效的诊断和治疗程序。这项建议是为了对他进行彻底的、定量的分析。猫视网膜中W细胞的感受野成分采用空间频率分析的方法。具体来说，这些实验将：(1)识别和表征视网膜W细胞的感受野成分允许与X细胞和Y细胞进行直接比较；(2)使其成为可能从以下方面分析这些细胞的复杂视觉行为明确定义的感受野成分之间的相互作用；(3) 为理解W细胞在视觉中的作用提供了基础信息处理和视觉感知；(4)提供依据探索潜在的细胞和突触机制 W细胞内感受野的形成。