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SPATIAL FREQUENCY ANALYSIS OF RETINA W-CELLS

视网膜 W 细胞的空间频率分析

基本信息

批准号：
3265152
负责人：
MICHAEL H ROWE
金额：
$ 8.67万
依托单位：
OHIO UNIVERSITY ATHENS
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-04-01 至 1993-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3265152
关键词：
cats eye disorder chemotherapy eye disorder diagnosis neural information processing retinal ganglion synapses visual fields visual perception

项目摘要

The mammalian retinal ganglion cell population comprises a number of functionally distinct groups of neuronrther been shown to be anatomically segregated as they course through the optic tract. In cats, a heterogeneous mixture of ganglion cells, often collectively referred to as W-cells, make up about 50% of the total population. Nevertheless, their receptive field properties have not been thoroughly analyzed and are not fully undestood. Consequently, we have littel understanding of their role in visual information processing, and are not yet able to explore the mechanisms underlying their response characteristics. Such knowledge is vital, however, in order to fully understand how various retinal perception, and will be important for the development of effective diagnostic and thereapeutic procedures. This proposal is to do a thorough and quantitative analysis of he receptive field components of W-cells in the cat retina in vivo, using the method of spatial frequency analysis. Specifically, these experiments will: (1) identify and characterize the receptive field components of retinal W-cells in terms which will allow direct comparisons with X- and Y-cells; (2) make it possible to analyze the complex visual behavior of these cells in terms of interactions amng well defined receptive field components; (3) provide a basis for understanding the role of W-cells in visual information processing and visual perception; (4) provide a basis for exploring the cellular and synaptic mechanisms underlying receptive field formation in W-cells.

哺乳动物视网膜神经节细胞群包括许多功能不同的神经元组已被证明是当它们穿过视束时在解剖学上是分离的。在猫中，神经节细胞的异质混合物通常统称为W细胞，约占总数的50% 人口。然而，它们的感受野属性没有被彻底分析，也没有被完全理解。因此，我们对它们在视觉中的作用知之甚少。信息处理，目前还无法探索其反应特征背后的机制。这样的然而，为了充分理解如何各种视网膜感知，对于开发有效的诊断和治疗程序。这个建议是要对他做一个彻底的、定量的分析。体内猫视网膜 W 细胞的感受野成分，采用空间频率分析的方法。具体来说，这些实验将：（1）识别并表征视网膜 W 细胞的感受野成分允许与 X 和 Y 细胞直接比较； (2) 使之成为可能分析这些细胞的复杂视觉行为明确定义的感受野成分之间的相互作用； (3) 为理解 W 细胞在视觉中的作用提供基础信息处理和视觉感知； (4)提供依据用于探索潜在的细胞和突触机制 W 细胞中感受野的形成。