FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
批准号:
3259928
负责人:
LARRY N THIBOS
金额:
$8.32万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-01-01 至 1991-03-31
关键词:
cats cell type color visions electroretinography evoked potentials fovea centralis retinae human subject microelectrodes neural information processing neuroanatomy neurogenesis neurophysiology psychophysics retinal ganglion sequential perception vision tests visual feedback visual fields visual perception visual photosensitivity visual stimulus
中文摘要
本提案的长期目标是了解
哺乳动物视网膜的组织原理
这种组织对联合国整体运作的重要性
视觉系统 视网膜神经节细胞是由
分成不同的功能类 每个班级负责
将视觉世界的特定视图呈现给特定的、高度的
大脑的特殊核团。 在这方面,
该项目的目标有三个方面。 首先,阐明
由不同种类的神经节细胞通过表征
并将单个细胞的视觉特性与
动物制备。 第二,将这些属性关联起来,
将这些特性应用于新描述的
视网膜电图,临床上用于诊断这种
人类疾病如多发性硬化症、视神经萎缩和青光眼。
第三,隔离限制视力和视网膜的因素
人类的周边视觉
不同类别的神经节细胞的代表性细胞将
通过将微电极引入到猫中,
麻醉动物的眼睛。 对比敏感度将是
在全频谱范围内针对正弦光栅刺激确定
空间频率和方向。 将进行比较
不同类型的电池在固定温度下的性能
视网膜的位置,也在同一类型的细胞之间,但在
不同的视网膜位置 与此同时,
从个体细胞的反应,视网膜电图将是
由第二电极记录。 将进行比较
在两组响应之间,以确定哪些类别的
视网膜神经节细胞,如果有的话,与这种模式相关-
诱发视网膜电图
人类受试者的周边视力将用
新发现的一类图案刺激是可见的,
无法妥善解决。 这种视觉模式,称为
混叠,通常只发生在外围领域,
理解正常周边视觉质量的关键
也是造成视力障碍的原因,
由于年龄相关而丧失中央凹视力的人,
遗传性或获得性黄斑变性。
英文摘要
The long-term objective of this proposal is to understand the
principles of organization of the mammalian retina and the
importance of such organization for the overall functioning of the
visual system. Retinal ganglion cells are known to be organized
into distinct, functional classes. Each class is responsible for
presenting a particular view of the visual world to specific, highly
specialized nuclei of the brain. In this context, the immediate
goals of this project are threefold. First, to elucidate the role
played by the different classes of ganglion cells by characterizing
and comparing the visual properties of individual cells in an
animal preparation. Second, to relate these properties to relate
these properties to a newly described component of the
electroretinogram that is used clinically for diagnosis of such
human diseases as multiple sclerosis, optic atrophy and glaucoma.
Third, to isolate the optical and retinal factors which limit
peripheral vision in man.
Representative cells of the different classes of ganglion cells will
be isolated for study in cat by introducing a microelectrode into
the eye of an anesthetized animal. Contrast sensitivity will be
determined for sinusoidal grating stimuli over the full spectrum of
spatial frequencies and orientations. Comparisons will be drawn
between the performance of different types of cells at fixed
retinal locations and also between cells of the same type but at
different retinal locations. Simultaneously with the recording of
responses from individuals cells, the electroretinogram will be
recorded by a second electrode. Comparisons will be drawn
between the two sets of responses to determine which classes of
retinal ganglion cell, if any, are correlated with this pattern-
evoked electroretinogram.
Peripheral vision in human subjects will be evaluated with a
newly-discovered class of patterned stimuli which are visible but
which cannot be resolved properly. This mode of vision, called
aliasing, ususally occurs only in the peripheral field and may hold
the keys to understanding the quality of normal peripheral vision
as well as the cause of visual dysfunction in the residual sight of
persons deprived of foveal vision because of age related,
hereditary, or acquired macular degeneration.
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ELECTRONICS
-
批准号:6949297
-
项目类别:
-
资助金额:$10.41万
-
财政年份:2005
-
负责人:LARRY N THIBOS
-
依托单位:
Shack-Hartman Corneal Topographer and Aberrometer
-
批准号:6442719
-
项目类别:
-
资助金额:$10.37万
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财政年份:2002
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负责人:LARRY N THIBOS
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依托单位:
SPATIALLY RESOLVED OPTOMETER FOR HUMAN EYES
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批准号:6015640
-
项目类别:
-
资助金额:$11.83万
-
财政年份:1999
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负责人:LARRY N THIBOS
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依托单位:
OPTICAL AND RETINAL LIMITS TO VISUAL PERFORMANCE
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批准号:2159288
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项目类别:
-
资助金额:$12.74万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:6721426
-
项目类别:
-
资助金额:$22.35万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:7144174
-
项目类别:
-
资助金额:$30.3万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:6126657
-
项目类别:
-
资助金额:$21.98万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:6635568
-
项目类别:
-
资助金额:$22.35万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:7684183
-
项目类别:
-
资助金额:$29.42万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
-
批准号:3259924
-
项目类别:
-
资助金额:$5.95万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
-
批准号:3259921
-
项目类别:
-
资助金额:$9.41万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO VISUAL PERFORMANCE
-
批准号:2159290
-
项目类别:
-
资助金额:$15.43万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:3259922
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
-
批准号:3259925
-
项目类别:
-
资助金额:$8.86万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
FUNCTIONAL ANALYSIS OF RETINAL GANGLION CELLS
-
批准号:3259923
-
项目类别:
-
资助金额:$5.72万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO VISUAL PERFORMANCE
-
批准号:2684491
-
项目类别:
-
资助金额:$15.64万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO VISUAL PERFORMANCE
-
批准号:2391668
-
项目类别:
-
资助金额:$14.75万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:7442115
-
项目类别:
-
资助金额:$28.83万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO VISUAL PERFORMANCE
-
批准号:2159289
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项目类别:
-
资助金额:$13.06万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE
-
批准号:7261190
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项目类别:
-
资助金额:$29.42万
-
财政年份:1984
-
负责人:LARRY N THIBOS
-
依托单位:
海外基金