OPTICAL AND RETINAL LIMITS TO HUMAN VISUAL PERFORMANCE

描述（由申请人提供）：我们研究计划的长期目标是了解光学和视网膜因素如何限制视觉体验的质量。我们在下一个项目期间的具体目标是（1）将波前像差测量的范围扩展到现实世界的视觉领域，（2）使用扩展的范围来研究临床和正常人群的视觉基本机制。结果将提高对眼睛单色像差和色差对视力的相对重要性、周边视网膜图像质量在近视中的作用、视网膜图像中颜色变化对空间视觉的作用、像差图像双眼总和的机制、屈光手术结果评估中瞳孔大小的重要性以及眼睛内部光学结构的性质的理解。项目1。通过开发和使用一种新颖的三色波前像差仪和光学质量的多色度量，将波前像差测量扩展到多色光的领域。我们将使用这些工具来量化眼像差对空间视觉、模糊感知和屈光的影响。项目2.将基于波前的视网膜图像质量分析扩展到正常和近视眼的周边视野。使用视网膜图像质量的多色指标，测试当前的假设，即近视眼的图像质量降低，周边视野的焦深更大，这可能会破坏正常的正视化并促进轴性近视。项目3。评估由眼像差引起的多色视网膜图像中颜色变化的重要性。我们将寻找证据，亮度主导空间视觉，但模糊符号取决于颜色。项目4。通过模拟不同视网膜图像的双眼整合，并使用回旋共振图像质量的度量来评估结果，将波前像差测量扩展到双眼视觉领域。项目5.扩大波前像差测量的动态范围和空间分辨率，用于临床异常眼的测量。检验瞳孔边缘的像差导致夜视投诉的假设。项目6.发展波前层析成像的新概念，通过沿着多条视线的一系列波前测量来表征眼睛光学系统的三维结构。

DESCRIPTION (provided by applicant): The long-term goal of our research program is to understand how optical and retinal factors constrain the quality of visual experience. Our specific aims for the next project period are (1) to expand the scope of wavefront aberrometry into the domain of real-world vision and (2) to use this expanded scope to investigate basic mechanisms of vision in clinical and normal populations. Results will improve understanding of the relative importance of ocular monochromatic and chromatic aberrations for vision, the role of peripheral retinal image quality in myopia, the role of color changes in the retinal image for spatial vision, the mechanism of binocular summation of aberrated images, the importance of pupil size in outcome assessment of refractive surgery, and the nature of the eye's internal optical structure. Project 1. Expand wavefront aberrometry into the domain of polychromatic light by developing and employing a novel, trichromatic wavefront aberrometer and polychromatic metrics of optical quality. We will use these tools to quantify the effects of ocular aberrations on spatial vision, blur perception, and refraction. Project 2. Expand wavefront-based analysis of retinal image quality into the peripheral visual field in normal and myopic eyes. Using polychromatic metrics of retinal image quality, test current hypotheses that myopic eyes have reduced image quality and a larger depth-of-focus in the peripheral field, which may disrupt normal emmetropization and promote axial myopia. Project 3. Evaluate the importance of color changes in the polychromatic retinal image caused by ocular aberrations. We will seek evidence that luminance dominates spatial vision but blur sign depends on color. Project 4. Expand wavefront aberrometry into the domain of binocular vision by simulating binocular integration of dissimilar retinal images and evaluating outcome with metrics of cyclopean image quality. Project 5. Expand the dynamic range and spatial resolution of wavefront aberrometry for measuring clinically abnormal eyes. Test the hypothesis that aberrations at the pupil margin causes night vision complaints. Project 6. Develop a new concept of wavefront tomography to characterize the 3-dimensional structure of the eye's optical system from a series of wavefront measurements along multiple lines-of-sight.