Shack-Hartman Corneal Topographer and Aberrometer

Shack-Hartman 角膜地形图仪和像差仪

• 批准号: 6442719
• 负责人: LARRY N THIBOS
• 金额: $ 10.37万
• 依托单位: QUARRYMEN OPTICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6442719
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; cornea; cornea disorder; corneal epithelium; diagnosis design /evaluation; eye disorder diagnosis; human subject; imaging /visualization /scanning; lens; morphometry; ophthalmoscopy

DESCRIPTION (provided by applicant): The long-term objective of our project is to design, build, and market an ophthalmic instrument that simultaneously measures corneal topography and optical aberrations of the human eye using wavefront sensing technology. From these measurements our instrument will provide a complete description of the refractive properties of the anterior cornea, the whole eye, and (by inference the crystalline lens. This optical description will include not only the routine refractive errors of defocus and astigmatism normally measured by present-day optometers and corneal topographers, but will also determine the irregular, higher-order optical aberrations which characterize optically abnormal eyes. Feasibility of the aberrometer component of this dual instrument was proven in a previous STTR grant. The purpose of this Phase-I proposal is to demonstrate feasibility of the corneal topography component by building and testing a prototype instrument using core technology developed with previous STTR support. The major technological advantages of using wavefront sensing technology for corneal topography include: (1) improved performance compared to Placido disk technology, (2) novel assessment of the optical aberrations of the crystalline lens, (3) novel assessment of tear film and keratoconic irregularities, (4) space- and cost-effectiveness derived from application of a single core technology to replace multiple instruments. A combined topographer! aberrometer will help provide wavefront-guided prescriptions for aberration corrections based on inter-ocular lenses, corneal photo-ablative surgery, or contact lenses. The long-term benefits will be improved patient care through improved diagnosis and treatment of optical defects of eyes. PROPOSED COMMERCIAL APPLICATION: Acorneal topographer is a clinical instrument used to map the surface geometry of the cornea of a human eye. Our design of a corneal topographer is based on wavefront sensing technology which has numerous advantages: lower cost, better accuracy, and integrated design with ophthalmic aberrometers. The same basic design concept could also be used to measure surfaces of lenses and mirrors in the optics industry.

描述(申请人提供)：我们项目的长期目标是 设计、制造和销售一种眼科仪器，同时 测量人眼的角膜地形图和光学像差 波前传感技术。通过这些测量，我们的仪器将 提供前房屈光状态的完整描述 角膜，整个眼睛，以及(由此推断的)晶状体。这是光学的 描述不仅包括散焦和散焦的常规屈光误差 散光通常由现代验光仪和角膜测量 地形师还将确定不规则的、更高阶的光学 以视觉异常的眼睛为特征的像差。该计划的可行性 此双仪器的像差计组件已在先前的STTR中得到验证 格兰特。此第一阶段提案的目的是论证以下项目的可行性 建立和测试样机的角膜地形图组件 使用与以前的STTR支持一起开发的核心技术。少校 角膜波前传感技术的技术优势 拓扑结构包括：(1)与Placido磁盘相比，性能更高 技术，(2)晶体光学像差的新评估 晶状体，(3)泪膜和角膜圆锥不规则的新评估，(4) 采用单一核心所产生的空间和成本效益 取代多种仪器的技术。一位综合的地形师！像差计 将有助于提供波前引导的像差矫正处方 基于人工晶状体、角膜光融性手术或隐形眼镜 隐形眼镜。长期的好处将是通过改善患者的护理 眼部光学缺陷的诊断和治疗。 建议的商业应用： 角膜地形图仪是一种临床仪器，用于绘制人眼角膜的表面几何图形。我们设计的角膜地形图仪基于波前传感技术，具有许多优点：成本更低，精度更高，并与眼像差计集成设计。同样的基本设计概念也可以用来测量光学行业中的透镜和反射镜的表面。

项目成果

Validation of a combined corneal topographer and aberrometer based on Shack-Hartmann wave-front sensing.

基于 Shack-Hartmann 波前传感的组合角膜地形图仪和像差仪的验证。

• DOI: 10.1364/josaa.21.000683
• 发表时间: 2004
• 期刊: Journal of the Optical Society of America. A, Optics, image science, and vision
• 作者: Zhou,Fan;Hong,Xin;Miller,DonaldT;Thibos,LarryN;Bradley,Arthur
• 通讯作者: Bradley,Arthur