SPATIALLY RESOLVED OPTOMETER FOR HUMAN EYES

我们项目的长期目标是设计、制造和销售下一代验光仪，用于全面测量眼睛的屈光状态。 这样的验光仪将不仅确定通常由临床验光仪测量的散焦和散光的常规屈光不正，而且还将确定高阶光学像差（例如，彗差、球面像差等）。其表征异常或病理性眼睛。 在该项目的第一阶段，我们的首要目标是根据公认的临床标准验证我们的设计概念。这将通过比较我们的原型系统与商业自动验光仪的结果和经验丰富的验光师确定的主观屈光度对人眼测量的屈光不正来完成。 我们的第二个目标是扩展我们目前的测量技术，使其足够强大，使常规测量的病理眼睛和健康的眼睛异常大的像差。 后一个目标将通过收集、分析和建模来自一组代表性的异常眼睛的样本数据来实现。 这些结果将为通过更好地理解病理性像差的基本光学基础来发现和实施新的数据处理算法提供基础。建议的商业应用该仪器将在基础验光实践中以及在屈光手术、眼间透镜植入物、角膜病理学的光学结果的临床研究中是有用的（例如圆锥角膜）、泪膜破裂、接触透镜治疗（例如角膜塑形术）、白内障的早期检测、或预期对眼睛的光学性能有影响的任何其它治疗或干预。

The long-term goal of our project is to design, build, and market a next-generation optometer for comprehensive measurement of the eye's refractive state. Such an optometer will determine not only the routine refractive errors of defocus and astigmatism normally measured by clinical optometers, but will also determine the higher-order optical aberrations (e.g. coma, spherical aberration, etc.) which characterize abnormal or pathological eyes. In Phase-I of this project, our first aim will be to validate our design concept against accepted clinical standards. This will be done by comparing refractive errors measured on human eyes by our prototype system with results from commercial autorefractors and with subjective refractions determined by an experienced optometrist. Our second aim will be to extend our current measurement techniques to make them robust enough to enable routine measurement of pathological eyes and healthy eyes with abnormally large aberrations. This latter aim will be achieved by collecting, analyzing, and modeling sample data from a representative set of abnormal eyes. The results will provide a basis for discovering and implementing new data processing algorithms through improved understanding of the fundamental optical basis of pathological aberrations. PROPOSED COMMERCIAL APPLICATION This instrument will be useful in basic optometric practice, and in clinical research studies of the optical outcome of refractive surgery, inter-ocular lens implants, corneal pathology (e.g, keratoconus), tear film breakup, contact lens therapy (e.g. orthokeratology), early detection of cataract, or any other treatment or intervention which is expected to have an impact on the optical performance of the eye.