SPATIALLY RESOLVED OPTOMETER FOR HUMAN EYES

我们项目的长期目标是设计、制造和销售下一代验光仪，用于全面测量眼睛的屈光状态。这种验光仪不仅能检测出临床验光仪通常检测到的离焦和散光等常规屈光不正，还能检测出异常或病态眼睛的高阶光学像差（如彗差、球差等）。在这个项目的第一阶段，我们的首要目标是根据公认的临床标准验证我们的设计概念。这将通过将我们的原型系统测量的人眼屈光不正与商业自动屈光仪的结果以及由经验丰富的验光师确定的主观屈光不正进行比较来完成。我们的第二个目标是扩展我们目前的测量技术，使它们足够强大，能够对具有异常大像差的病理眼睛和健康眼睛进行常规测量。后一个目标将通过收集、分析和建模来自一组具有代表性的异常眼睛的样本数据来实现。这些结果将为发现和实现新的数据处理算法提供基础，通过提高对病理像差的基本光学基础的理解。该仪器将用于基本的验光实践，以及屈光手术、眼间晶状体植入、角膜病理（如圆锥角膜）、泪膜破裂、隐形眼镜治疗（如角膜塑形术）、白内障早期检测或任何其他预计会对眼睛的光学性能产生影响的治疗或干预的光学结果的临床研究。

The long-term goal of our project is to design, build, and market a next-generation optometer for comprehensive measurement of the eye's refractive state. Such an optometer will determine not only the routine refractive errors of defocus and astigmatism normally measured by clinical optometers, but will also determine the higher-order optical aberrations (e.g. coma, spherical aberration, etc.) which characterize abnormal or pathological eyes. In Phase-I of this project, our first aim will be to validate our design concept against accepted clinical standards. This will be done by comparing refractive errors measured on human eyes by our prototype system with results from commercial autorefractors and with subjective refractions determined by an experienced optometrist. Our second aim will be to extend our current measurement techniques to make them robust enough to enable routine measurement of pathological eyes and healthy eyes with abnormally large aberrations. This latter aim will be achieved by collecting, analyzing, and modeling sample data from a representative set of abnormal eyes. The results will provide a basis for discovering and implementing new data processing algorithms through improved understanding of the fundamental optical basis of pathological aberrations. PROPOSED COMMERCIAL APPLICATION This instrument will be useful in basic optometric practice, and in clinical research studies of the optical outcome of refractive surgery, inter-ocular lens implants, corneal pathology (e.g, keratoconus), tear film breakup, contact lens therapy (e.g. orthokeratology), early detection of cataract, or any other treatment or intervention which is expected to have an impact on the optical performance of the eye.