BIOMEDICAL SEPARATIONS: FIELD-FLOW FRACTIONATION

生物医学分离：场流分离

• 批准号: 3268159
• 负责人: J C GIDDINGS
• 金额: $ 13.79万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-02-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3268159
• 关键词: chromatography; mathematics

One goal of this project is the general improvement and expansion of the methodology of field-flow fractionation (FFF). Efforts will be made to opotimize speed, resolution, range and accuracy through improved channels, seal design, new FFF systems and improved procedures. Collaborative projects will be undertaken to extend the applicability of FFF into diverse biomedical fields. These projects will involve the separation and characterization of viral aggregates, subcellular particles, bile micelles, synthetic blood, viral particles, acidic peptides, polynucleotides, and the protein structures in cataract impaired lenses. Finally, theoretical studies will be continued to clarify the relationship between diverse separation methods.

该项目的目标之一是全面改进和扩展 场流分级（FFF）方法。 将努力 通过改进的通道优化速度、分辨率、范围和准确性， 密封设计、新的 FFF 系统和改进的程序。 协作性 将开展项目以将 FFF 的适用性扩展到多种领域 生物医学领域。 这些项目将涉及分离和 病毒聚集体、亚细胞颗粒、胆汁胶束的表征， 合成血液、病毒颗粒、酸性肽、多核苷酸和 白内障受损晶状体中的蛋白质结构。 最后，理论上 将继续进行研究以澄清不同之间的关系 分离方法。