DEVELOPMENT OF THE VEP TO LUMINANCE MODULATION

亮度调制 VEP 的开发

• 批准号: 3265846
• 负责人: RICHARD SREBRO
• 金额: $ 10.77万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265846
• 关键词: adult human (21+); amblyopia; child physical development; diagnosis design /evaluation; electrophysiology; evoked potentials; eye disorder diagnosis; human subject; infant human (0-1 year); vision disorders; visual fields; visual perception; visual stimulus

The project proposed here concerns the validation of a new test procedure to assess infant visual function and to detect amblyopia in the first year of life. The test uses as an input a pseudorandom sequence of luminance modulation and as an output the visually evoked potential. The test is simple to conduct, requires only 43 secs of data collection to test an eye, is not affected by refractive errors or accommodation, and requires minimal cooperation from the infant subject. The stimulus mimics band-pass limited white noise but contains a periodicity which allows signal averaging. In a preliminary study reported here, a method is described to extract the maximum input frequency driving the response (MDF). Using 14o nearly homogeneous fields a developmental sequence was estimated in 19 infants in which MDF ranged from a 4 Hz at 4 weeks to 13 Hz at 44 weeks postnatal age. The adult maximum driving frequency was 19 Hz. Surprisingly, 6 adult amblyopes all had unequivocally abnormal test results in their amblyopic eyes suggesting a developmental arrest at 3 months of age. The proposal concerns both the implementation of the test in a larger normal infant population and the exploration of the reason for the results in adult amblyopes.

这里提出的项目涉及一个新的测试程序的验证 评估婴儿的视觉功能，并在第一年检测弱视 生命 该测试使用亮度的伪随机序列作为输入 调制并作为视觉诱发电位的输出。 测试 操作简单，测试一只眼睛只需要43秒的数据收集， 不受屈光不正或调节的影响， 婴儿主体的合作。 刺激模仿带通限制 白色噪声，但包含允许信号平均的周期性。 中 初步研究报告在这里，一种方法是描述提取的 驱动响应的最大输入频率（kHz）。 使用14o几乎 在19名婴儿中估计了一个发育序列， 其频率范围从出生后4周的4Hz到出生后44周的13Hz。 成人最大驱动频率为19 Hz。 令人惊讶的是，6名成人 所有弱视者的弱视测试结果都明确异常， 3个月大时出现发育停滞。 该提案 涉及在较大的正常婴儿中实施测试 人口和探索的原因，结果在成人 弱视