LOCALIZING BRAIN ACTIVITY WITH VEP'S

使用 VEP 定位大脑活动

• 批准号: 3266376
• 负责人: RICHARD SREBRO
• 金额: $ 20.2万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3266376
• 关键词: brain electrical activity; brain mapping; digital imaging; evoked potentials; human subject; magnetic resonance imaging; neural information processing; phantom model; scalp; vision

DESCRIPTION (Investigator's abstract): This project addresses the problem of localizing brain activity in humans from visually evoked potential fields measured on the scalp. Previous work has set the localization problems in terms of defining brain current sources usually in the form of current dipoles. This leads to a problem that is ill posed, i.e., no unique solution is possible and to an undesirable linkage between the localization problem and specific models of how current is generated in the brain. One approach to ill-posed problems is to solve a closely related problem that provides the needed information but which has a unique solution. Brain surface potentials are uniquely specified by scalp potential fields and localize brain activity with good resolution. No assumptions about brain electrogenesis are required. Computation of brain surface potentials fields from scalp potential fields does require quantitative anatomy of the scalp and brain and accurate measurements of electrode position. Techniques to accomplish this using a 3-D digitizer and magnetic resonance imaging of the brian are described. Verification is proposed by means of a life-like model of the human head based on a human skull and by mapping the retino-topic projections to striate cortex in humans. The ability to localize brian activity with VEP's would provide a very useful tool for basic and clinical research in vision because the temporal resolution of VEP's is much better than that of position emission tomography, the principal method now available for regional brain activity measurement. As such it could provide the means to track brain activity as it proceeds in time after a stimulus is presented. This could be useful in understanding normal visual processing, in defining abnormal processing, and in studying adaptations to brain injury.

描述（研究者摘要）：该项目解决了问题 从视觉诱发电位中定位人类大脑活动 在头皮上测量的场。 以前的工作已经设置了本地化 在定义脑电流源方面的问题，通常以 电流偶极子 这导致了一个不适定的问题，即，没有 唯一的解决方案是可能的，并对一个不希望的联系之间的 本地化问题和电流如何在 个脑袋 解决不适定问题的一种方法是解决一个密切相关的 提供所需信息但具有唯一 溶液 大脑表面电位由头皮唯一指定 潜在的领域和本地化的大脑活动具有良好的分辨率。 没有 需要关于脑电发生的假设。 脑计算 头皮电位场的表面电位场 头皮和大脑的定量解剖以及 电极位置 使用3-D数字化仪完成此操作的技术 和脑的磁共振成像。 验证提出了一个逼真的人头模型 基于人类头骨，并通过将视网膜投影映射到 人类的纹状皮层 定位大脑活动的能力 VEP将为基础和临床研究提供一个非常有用的工具， 因为VEP的时间分辨率比VEP的时间分辨率好得多， 位置发射断层扫描，现在的主要方法， 局部脑活动测量。 因此，它可以提供一种手段， 在刺激出现后及时跟踪大脑活动。 这可能有助于理解正常的视觉处理， 异常处理，以及研究脑损伤的适应性。