DEVELOPMENT OF THE VEP TO LUMINANCE MODULATION

亮度调制 VEP 的开发

• 批准号: 3265848
• 负责人: RICHARD SREBRO
• 金额: $ 11.05万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265848
• 关键词: adult human (21+); amblyopia; child physical development; diagnosis design /evaluation; electrophysiology; evoked potentials; eye disorder diagnosis; human subject; infant human (0-1 year); vision disorders; visual fields; visual perception; visual stimulus

The project proposed here concerns the validation of a new test procedure to assess infant visual function and to detect amblyopia in the first year of life. The test uses as an input a pseudorandom sequence of luminance modulation and as an output the visually evoked potential. The test is simple to conduct, requires only 43 secs of data collection to test an eye, is not affected by refractive errors or accommodation, and requires minimal cooperation from the infant subject. The stimulus mimics band-pass limited white noise but contains a periodicity which allows signal averaging. In a preliminary study reported here, a method is described to extract the maximum input frequency driving the response (MDF). Using 14o nearly homogeneous fields a developmental sequence was estimated in 19 infants in which MDF ranged from a 4 Hz at 4 weeks to 13 Hz at 44 weeks postnatal age. The adult maximum driving frequency was 19 Hz. Surprisingly, 6 adult amblyopes all had unequivocally abnormal test results in their amblyopic eyes suggesting a developmental arrest at 3 months of age. The proposal concerns both the implementation of the test in a larger normal infant population and the exploration of the reason for the results in adult amblyopes.

这里提出的项目涉及一个新的测试程序的验证

项目成果

An analysis of the VEP to luminance modulation and of its nonlinearity.

亮度调制的 VEP 及其非线性分析。

• DOI: 10.1016/0042-6989(92)90194-n
• 发表时间: 1992
• 期刊: Vision research
• 影响因子: 1.8
• 作者: Srebro,R