DEVELOPMENT OF THE VEP TO LUMINANCE MODULATION

这里提出的项目涉及一种新的测试程序的验证 在一岁时评估婴儿的视觉功能并检测弱视 生活的一部分。该测试使用一个伪随机亮度序列作为输入 调制和作为输出的视觉诱发电位。测试是 操作简单，只需要43秒的数据收集就可以测试一只眼睛， 不受屈光不正或调节的影响，并且需要最小限度的 来自婴儿主体的合作。刺激模拟有限的带通 白噪声，但包含允许信号平均的周期性。在一个 初步研究报告，描述了一种方法来提取 驱动响应的最大输入频率(MDF)。使用近140度 同质场对19名婴儿的发育顺序进行了估计。 MDF在4周龄时为4 Hz，在44周龄时为13 Hz。 成人最大驾驶频率为19赫兹。令人惊讶的是，6名成年人 所有弱视患者的弱视检查结果都明显异常。 眼睛显示3个月大时发育停滞。这项建议 涉及到在较大的正常婴儿中实施该测试 人口与成人致病原因的探讨 弱视患者。

The project proposed here concerns the validation of a new test procedure to assess infant visual function and to detect amblyopia in the first year of life. The test uses as an input a pseudorandom sequence of luminance modulation and as an output the visually evoked potential. The test is simple to conduct, requires only 43 secs of data collection to test an eye, is not affected by refractive errors or accommodation, and requires minimal cooperation from the infant subject. The stimulus mimics band-pass limited white noise but contains a periodicity which allows signal averaging. In a preliminary study reported here, a method is described to extract the maximum input frequency driving the response (MDF). Using 14o nearly homogeneous fields a developmental sequence was estimated in 19 infants in which MDF ranged from a 4 Hz at 4 weeks to 13 Hz at 44 weeks postnatal age. The adult maximum driving frequency was 19 Hz. Surprisingly, 6 adult amblyopes all had unequivocally abnormal test results in their amblyopic eyes suggesting a developmental arrest at 3 months of age. The proposal concerns both the implementation of the test in a larger normal infant population and the exploration of the reason for the results in adult amblyopes.