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TOPOLOGY OF THE VISUALLY EVOKED POTENTIAL

视觉诱发电位的拓扑

基本信息

批准号：
3259735
负责人：
RICHARD SREBRO
金额：
$ 13.81万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-08-01 至 1990-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3259735
关键词：
amblyopia brain electrical activity chronic brain damage diagnosis design /evaluation electrodes evoked potentials eye disorder diagnosis glaucoma human subject mental retardation neurophysiology noninvasive diagnosis stimulus /response visual cortex visual fields visual fixation visual stimulus

项目摘要

The relationship between the scalp topology of the visually evoked potential (VEP) and the stimulus paradigm that causes it will be studied using a new method that allows noninvasive localization of active cortical areas in humans with a resolution of about 1 cm. The method is based on estimating the Laplacian of the VEP field on the scalp by recording second differences of the potential field along orthogonal directions from a multielectrode array. The following problems of basic neurophysiological interest will be addressed: (1) cortical localization of patterned stimuli presented to different parts of the visual field (retinotopic map of the cortex). (2) cortical localization of activity subserving visual object recognition. The retinotopic map will be used to approach several related clinical problems: (1) the selection of electrode placements to discriminate foveal signals in the VEP to wide field stimuli as an aid in the evaluation of patients with opaque media, infants, brain-damaged and mentally retarded patients, (2) the selection of electrode placements to discriminate signals from visual field zones 10 to 25 degrees from fixation as an aid to the objective detection and monitoring of field defects in glaucoma, (3) the objective measurement of eccentric fixation in amblyopia and (4) the objective detection of hemianopic and quadrantanopic field defects in neuroophthalmological problems.

视觉诱发电位的头皮拓扑结构之间的关系视觉诱发电位（VEP）和刺激范式，导致它将被研究使用一种新的方法，人体内的区域，分辨率约为1厘米。该方法基于通过记录第二次VEP来估计头皮上VEP场的拉普拉斯算子，势场沿沿着正交方向与多电极阵列基本神经生理学的以下问题感兴趣是：（1）模式刺激的皮层定位呈现给视野的不同部分（视网膜的视网膜定位图，皮质）。 (2)视物相关活动的皮层定位识别. 视网膜定位图将被用来接近几个相关的临床问题：（1）电极放置的选择，将VEP中的中央凹信号区分为宽场刺激，作为辅助，评估患者与不透明的媒体，婴儿，脑损伤，弱智患者，（2）电极放置的选择，辨别来自与注视成10至25度的视野区的信号作为对现场缺陷的客观检测和监控的辅助手段，青光眼;（3）弱视偏心注视的客观测量（4）偏盲视野和象限视野的客观检测神经眼科问题的缺陷。