Underpinning UK Bioscience Research with high-throughput single molecule sequencing

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The genomics revolution is entering its third phase with the advent of technologies that can generate single molecule DNA sequencing data extending 100s of kilobases. Long DNA sequence reads can be used to generate high quality reference genomes, to better understand gene expression, and to sequence and sort DNA in complex mixtures such as environmental samples of soil or water. The Pacific Biosciences Sequel II System is a new long-read DNA sequencing platform that generates extremely large amounts of data at an affordable cost. A key feature of Sequel II is that it can generate highly accurate long reads, by reading a DNA molecule multiple times to correct errors. This grant will acquire the Sequel II platform, the first in Scotland, embed this within Edinburgh Genomics, and allow us to offer low-cost, high quality long read sequencing as a service to the biological and biotechnology research community. We will use the investment to support researchers who want to generate genomic data for diverse topics such as agriculture, biotechnology, genetics, immunology and synthetic biology.