DESIGN AND EVALUATION OF AN ARTIFICIAL SKIN

人造皮肤的设计和评估

• 批准号: 3271976
• 负责人: IOANNIS V YANNAS
• 金额: $ 19.75万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3271976
• 关键词: biomaterial development /preparation; biomaterial evaluation; burns; computer data analysis; histochemistry /cytochemistry; human tissue; immunochemistry; mass spectrometry; mathematical model; membrane permeability; mucopolysaccharides; radiotracer; scanning electron microscopy; scars; silicone rubber; skin transplantation; tensile strength; tissue /cell culture; transplantation; wound healing

Our long-term goal continues to be to design and evaluate clinically a polymeric biodegradable membrane which can be used to treat full-thickness skin wounds in patients with extreme skin loss. Our objectives for the coming year are a) continuation of ultrastructural studies of Stage 2 grafts on guinea pigs in the immediate post-grafting period, 3-21 days post-grafting b) continue human trials of Stage 2 membranes and c) complete the study of the effect of graft degradation rate and pore size on wound contraction rate of guinea pig wounds.

我们的长期目标仍然是设计和评估一种临床应用 可用于处理全厚度的聚合物生物降解膜 皮肤创伤患者皮肤极度脱落。 我们来年的目标是)继续发展超微结构 豚鼠移植后即刻第2期移植物的研究 移植后3-21天，b)继续第二阶段的人体试验 膜和c)完成对接枝降解率影响的研究 毛孔大小对豚鼠创面收缩速率的影响。