课题基金 / 基金详情

DESIGN AND EVALUATION OF AN ARTIFICIAL SKIN

DESIGN AND EVALUATION OF AN ARTIFICIAL SKIN
人造皮肤的设计和评估
批准号：
3271975
负责人：
IOANNIS V YANNAS
金额：
$19.45万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-04-01 至 1988-03-31
来源：
https://reporter.nih.gov/project-details/3271975
关键词：
biomaterial development /preparation biomaterial evaluation burns computer data analysis histochemistry /cytochemistry human tissue immunochemistry mass spectrometry mathematical model membrane permeability mucopolysaccharides radiotracer scanning electron microscopy scars silicone rubber skin transplantation tensile strength tissue /cell culture transplantation wound healing

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中文摘要
翻译
我们的长期目标仍然是设计和临床评估一种 可用于治疗全厚度的聚合物生物可降解膜 皮肤严重缺损患者的皮肤伤口。 我们明年的目标是：a）继续进行超微结构 移植后即刻对豚鼠进行的第2阶段移植研究 移植后3-21天的阶段B）继续第2阶段的人体试验 膜和c）完成接枝降解速率的影响的研究 和孔径对豚鼠伤口收缩率的影响。
英文摘要
Our long-term goal continues to be to design and evaluate clinically a polymeric biodegradable membrane which can be used to treat full-thickness skin wounds in patients with extreme skin loss. Our objectives for the coming year are a) continuation of ultrastructural studies of Stage 2 grafts on guinea pigs in the immediate post-grafting period, 3-21 days post-grafting b) continue human trials of Stage 2 membranes and c) complete the study of the effect of graft degradation rate and pore size on wound contraction rate of guinea pig wounds.
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