DYNAMIC PATTERN IN CHEMICALLY-REACTING SYSTEMS

化学反应系统中的动态模式

• 批准号: 3276613
• 负责人: HANS G OTHMER
• 金额: $ 17.58万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3276613
• 关键词: Dictyostelium; biological signal transduction; cell aggregation; cell cell interaction; cell growth regulation; cell migration; chemoattractants; chemotaxis; computer simulation; cyclic AMP; growth media; mathematical model; model design /development; physiology

DESCRIPTION: (Adapted from the applicant's abstract) The long range objectives of this research are to further the understanding of the dynamical behavior of aggregates of interacting cells and to apply this knowledge to problems of cell movement and pattern formation in developmental biology and to problems in physiology. The proposed research falls into three major categories: (l) studies on cell movement and pattern formation in Dictyostelium discoideum, (2) studies on pattern formation in limb development, and (3) studies on the dynamics of excitable media. The specific aims in (l) are: (i) to develop a model for the movement of individual cells on a substrate, both in the absence and the presence of chemotactic fields, (ii) to use the model to understand the motion of the slug stage of Dictyostelium discoideum and to explore various patterns of cell interactions that can produce tissue movement (iii) to develop a model for pattern formation and regulation in the slug stage, and (iv) to develop continuum descriptions for tissue movement. The objectives in (2) are: (i) to develop a two-dimensional model of limb development that incorporates growth and specialized regions (the AER and the ZA) on the boundary for the purpose of understanding their interaction during pattern formation in the developing limb, and (ii) to affect the patterning process and the final shape of the limb. The objectives in (3) are: (i) to study the dynamics of spiral waves in simple excitable systems in order to understand how the frequency and wavelength of the waves are set, how stable they are under various types of perturbations, and how they disappear when the excitability or rate of recovery of the medium is changed, and (ii) to study models for the dynamics of forced excitable systems with a view towards understanding the patterns of phase-locking and propagation block in spatially-distributed oscillatory or excitable systems. The work on cell movement and pattern formation in Dictyostelium discoideum will elucidate the role of cell-cell interactions, chemotaxis and cyclic AMP signalling in the motion and cell proportioning that occur in the slug stage of Dictyostelium discoideum. The work on pattern formation in limb development will further our understanding of normal development and perhaps point to the basis of various types of defects in limb development. Furthermore, the knowledge gained on that problem will contribute to our understanding of the role of growth and cell-cell interactions in the morphogenesis of other systems. The studies on excitable systems will lead to a theoretical basis for predicting fundamental properties of spiral waves, a basis that can be used in devising protocols for extinguishing such waves. These results, coupled with those on the dynamics of forced excitable systems, will expand our understanding of the origin of various types of cardiac arrythmias and how they may be prevented or controlled.

描述：（改编自申请人的摘要） 本研究的目的是进一步了解 相互作用的细胞聚集体的动力学行为，并将其应用于 知识的细胞运动和图案形成的问题， 发育生物学和生理学问题。 拟议研究 福尔斯分为三大类：（l）对细胞运动的研究， 盘基网柄藻格局形成的研究（2）格局的研究 肢体发育中的兴奋性神经元的形成;（3）兴奋性神经元的动态研究 媒体 （l）中的具体目标是：（i）为 单个细胞在基底上的移动，无论是在不存在的情况下还是在存在的情况下， 趋化场的存在，（ii）使用该模型来理解 盘基网柄藻蛞蝓阶段的运动，并探讨各种 可以产生组织运动的细胞相互作用的模式（iii）， 开发段塞阶段的井网形成和调整模型， (iv)来发展组织运动的连续描述。 目标 在（2）中：（i）开发肢体发育的二维模型 包括增长和专门区域（AER和ZA）， 为了了解它们之间的互动， 在发展中的肢体图案形成，和（ii）影响图案 过程和肢体的最终形状。 第（3）项的目标是：（i） 研究简单可激发系统中螺旋波的动力学， 去理解波的频率和波长是如何被设定的， 它们在各种扰动下是稳定的，以及它们如何 当介质的兴奋性或恢复率 改变，和（ii）研究模型的动态强迫兴奋 系统，以期了解锁相模式， 在空间分布的振荡或可兴奋的传播块 系统. 盘基网柄藻细胞运动和格局形成的研究 将阐明细胞与细胞相互作用、趋化性和周期性的作用 AMP信号在运动和细胞比例发生在蛞蝓 Dictyosteelium discoideum阶段。 肢体中的模式形成工作 发展将进一步加深我们对正常发展的理解， 也许指出了肢体发育中各种类型缺陷的基础。 此外，在这一问题上获得的知识将有助于我们 了解生长和细胞间相互作用在 其他系统的形态发生。 对可兴奋系统的研究将导致 为预测螺旋线的基本性质提供了理论依据 波，一个基础，可用于制定协议， 这样的波浪。 这些结果，再加上那些对动力学的强迫 兴奋系统，将扩大我们对各种起源的理解 心律失常的类型以及如何预防或控制。