Dynamic Pattern in Chemically Reacting Systems

描述（由申请人提供）：本研究的长期目标是进一步了解信号转导和基因控制网络，特别是因为它们与发育生物学中的模式形成有关。这项工作涉及特定生物系统的分析，以及一般分析和计算技术的发展。主要项目包括：（1）果蝇模式形成和肢体发育的研究;（2）E.杆菌（1）的目的是发展、分析和测试果蝇早期胚胎发育中沿着背腹轴的图案化模型，以及果蝇翼盘中的图案化和生长及形状变化的影响。（2）的目的是理解E.大肠杆菌通过分析模型的受体聚类，将新的受体模型纳入一个完整的模型的趋化信号转导途径，整合这个模型与模型的鞭毛电机的控制，并了解宏观，人口水平的空间模式，使用详细的模型的个人行为。在这两个项目中，一个重要的任务将是了解信号转导和基因控制网络的拓扑结构如何影响网络中组件的随机波动，从而了解什么样的相互作用模式确保可靠的输出。（1）的研究将促进我们对发育生物学基本过程的理解，如信号传导、基因控制和模式形成。更好地理解这些基本过程将有助于更好地理解系统如何对其环境作出反应，正常的发展如何被破坏，以及如何纠正异常发展。（2）中的工作结果将有助于我们理解细胞外信号如何转换为细菌的运动控制，个体的微观行为如何反映在种群水平的描述中，以及营养供应和趋化因子如何控制模式的形成。这一结果将提供深入了解参与生物膜形成的因素。

DESCRIPTION (provided by applicant): The long range objectives of this research are to further our understanding of signal transduction and gene control networks, particularly as they relate to pattern formation in developmental biology. The work involves analysis of specific biological systems, as well as the development of general analytical and computational techniques. The (major projects are: (1) studies on pattern formation in Drosophila and limb development, and (2) studies on signal transduction, motor control and pattern formation in E. coli. The aim under (1) are the development, analysis and testing of models of patterning along the dorsal-ventral axes in early embryonic development of Drosophila, and of patterning and the effects of growth and shape changes in the wing discs in Drosophila The aims under (2) are to understand the origin of high gain in signal transduction in E. coli by analyzing models of receptor clustering, to incorporate new receptor models into a complete model for the chemotactic signal transduction pathway, to integrate this model with a model for the control of the flagellar motor, and to understand macroscopic, population-level spatial patterns using detailed models of individual behavior. In both of these projects a significant task will be to understand how the topology of signal transduction and gene control networks affects the stochastic fluctuations of components in the network, and thereby to understand what patterns of interactions ensure reliable outputs. The research in (1) will advance our understanding of basic processes in developmental biology such as signal transduction, gene control, and pattern formation. A better understanding of these fundamental processes will contribute to a better understanding of how systems respond to their environment, how normal development can be disrupted and perhaps how abnormal development can be corrected. The results of the work in (2) will contribute to our understanding of how extracellular signals are transduced into motor control in bacteria, how the microscopic behavior of individuals is reflected in population-level descriptions, and how nutrient supply and chemotactic factors control pattern formation. This result will provide insight into factors that are involved in the formation of biofilms.