DYNAMIC PATTERN IN CHEMICALLY-REACTING SYSTEMS

化学反应系统中的动态模式

• 批准号: 3276612
• 负责人: HANS G OTHMER
• 金额: $ 17.77万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3276612
• 关键词: Dictyostelium; biological signal transduction; cell aggregation; cell cell interaction; cell growth regulation; cell migration; chemoattractants; chemotaxis; computer simulation; cyclic AMP; growth media; mathematical model; model design /development; physiology

DESCRIPTION: (Adapted from the applicant's abstract) The long range objectives of this research are to further the understanding of the dynamical behavior of aggregates of interacting cells and to apply this knowledge to problems of cell movement and pattern formation in developmental biology and to problems in physiology. The proposed research falls into three major categories: (l) studies on cell movement and pattern formation in Dictyostelium discoideum, (2) studies on pattern formation in limb development, and (3) studies on the dynamics of excitable media. The specific aims in (l) are: (i) to develop a model for the movement of individual cells on a substrate, both in the absence and the presence of chemotactic fields, (ii) to use the model to understand the motion of the slug stage of Dictyostelium discoideum and to explore various patterns of cell interactions that can produce tissue movement (iii) to develop a model for pattern formation and regulation in the slug stage, and (iv) to develop continuum descriptions for tissue movement. The objectives in (2) are: (i) to develop a two-dimensional model of limb development that incorporates growth and specialized regions (the AER and the ZA) on the boundary for the purpose of understanding their interaction during pattern formation in the developing limb, and (ii) to affect the patterning process and the final shape of the limb. The objectives in (3) are: (i) to study the dynamics of spiral waves in simple excitable systems in order to understand how the frequency and wavelength of the waves are set, how stable they are under various types of perturbations, and how they disappear when the excitability or rate of recovery of the medium is changed, and (ii) to study models for the dynamics of forced excitable systems with a view towards understanding the patterns of phase-locking and propagation block in spatially-distributed oscillatory or excitable systems. The work on cell movement and pattern formation in Dictyostelium discoideum will elucidate the role of cell-cell interactions, chemotaxis and cyclic AMP signalling in the motion and cell proportioning that occur in the slug stage of Dictyostelium discoideum. The work on pattern formation in limb development will further our understanding of normal development and perhaps point to the basis of various types of defects in limb development. Furthermore, the knowledge gained on that problem will contribute to our understanding of the role of growth and cell-cell interactions in the morphogenesis of other systems. The studies on excitable systems will lead to a theoretical basis for predicting fundamental properties of spiral waves, a basis that can be used in devising protocols for extinguishing such waves. These results, coupled with those on the dynamics of forced excitable systems, will expand our understanding of the origin of various types of cardiac arrythmias and how they may be prevented or controlled.

描述：(改编自申请者的摘要)远程 本研究的目的是加深对这一现象的认识 相互作用细胞聚集体的动力学行为及其应用 对细胞运动和图案形成问题的认识 发展生物学和生理学中的问题。拟议的研究 主要分为三大类：(L)细胞运动研究和 盘基网眼菌的花纹形成，(2)花纹的研究 肢体发育中的形成，以及(3)兴奋性运动的动力学研究 媒体。(L)的具体目标是：(一)开发一个模型，用于 单个细胞在底物上的运动，无论是在不存在的情况下还是在 化学趋化场的存在，(Ii)使用模型来理解 盘基盘基盘基菌(Dictyostelialdiscoideum)的螺状期的运动及不同种类的探索 可产生组织运动的细胞相互作用模式(III) 开发一个在段塞阶段形成和调节模式的模型，以及 (4)发展对组织运动的连续描述。目标 在(2)中是：(I)开发肢体发育的二维模型 将增长和专业区域(AER和ZA)整合在一起 边界的目的是为了了解它们在 在发育中的肢体中形成图案，以及(Ii)影响图案形成 过程和肢体的最终形状。第(3)项的目标是：(I) 有序研究简单可激发系统中螺旋波的动力学 为了了解波的频率和波长是如何设置的，如何 它们稳定地处于各种类型的扰动下，以及它们是如何 当介质的兴奋性或恢复率为 改变，以及(Ii)研究强迫可兴奋的动力学模型 系统，以期了解锁相和 空间分布振荡或可激发中的传播阻挡 系统。 盘基网柄菌中细胞运动和模式形成的研究 将阐明细胞-细胞相互作用、趋化和循环的作用 运动中的AMP信号和在弹状物中发生的细胞比例 盘基网眼菌的发育阶段。肢体花纹形成的研究进展 发展将加深我们对正常发展和 或许指向各种肢体发育缺陷的基础。 此外，在这个问题上获得的知识将有助于我们 理解生长和细胞-细胞相互作用在细胞生长中的作用 其他系统的形态发生。对可激发系统的研究将导致 为预测螺旋线的基本性质奠定了理论基础 波，一个可以用来设计灭火协议的基础 这样的海浪。这些结果，再加上那些关于强迫的动力学的结果 兴奋系统，将扩大我们对各种起源的理解 心律失常的类型以及如何预防或控制。