PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS

本文重点介绍了周环反应在新材料中的应用。 几类重要有机化合物的合成方法学 化合物。环丙基硼烷的合成和反应将是 研究，这种化学将被普遍应用， 各种替代和功能化的立体控制路线 环丙烷衍生物。高度立体控制的[41]节育术 涉及加速Sigmatrotic重排的战略将是 发展成为合成五元碳环的通用方法 化合物。电环反应与[2 2]和[4 2]环加成反应 乙烯基烯烃将在一般方法的范围内进行研究 脂环和芳香族化合物的合成。这一点的应用 一种高度收敛的立体控制全合成方法 将检查抗病毒抗生素Asco氯in。

This proposal focuses on the application of pericyclic reactions in new methodology for the synthesis of several important classes of organic compounds. The synthesis and reactions of cyclopropylboranes will be investigated, and this chemistry will be applied in general, stereocontrolled routes to a variety of substituted and functionalized cyclopropane derivatives. Highly stereocontrolled [4+1] annulation strategies involving accelerated sigmatropic rearrangements will be developed as general methods for the synthesis of five-membered carbocyclic compounds. Electrocyclic reactions and [2+2] and [4+2] cycloadditions of vinylketenes will be investigated in the context of general methods for the synthesis of alicyclic and aromatic compounds. The application of this methodology in a highly convergent stereocontrolled total synthesis of the antiviral antibiotic ascochlorin will be examined.