PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS

描述：首席调查员表示，此次续签 建议重点介绍周环反应在新能源领域中的应用 几类重要化合物的合成方法学 碳环和杂环有机化合物。 第一部分描述了新方法的发展。 四元、五元和六元环系的合成。一种新方法 对于环丁酮的合成正在研究中，新的 生成五元环和六元环的环加成反应为 基于(三烷基硅基)乙烯基乙烯酮作为 四碳合成积木。首席调查员注意到 合成2，4-环己二烯酮的一种新方法将是 作为有效合成方法的关键步骤开发和使用 抗肿瘤药物紫杉醇的A环合成子。 据指出，提案的第二部分说明了进一步的 开发一条通向高度的区域控制环流路线 取代芳香族和杂芳族化合物。校长 调查员指出，将这一方法应用于 将研究生物活性天然产物的合成，并 该特定靶标化合物包括抗生素苯丙酮 二萜阿托品，一种低胆固醇的抗菌素， 和抗肿瘤二萜紫杉素B，此外， 分子内烯炔环加成策略在分子内环化反应中的应用 四环呋喃苯二烯二萜的全合成 沙维莱酮也将接受检查。

DESCRIPTION: The principal investigator indicates that this renewal proposal focuses on the application of pericyclic reactions in new methodology for the synthesis of several important classes of carbocyclic and heterocyclic organic compounds. It is stated that part I describes the development of new methods for the synthesis of four-, five-, and six-membered ring systems. A new method for the synthesis of cyclobutanones is to be investigated, and new cycloadditions leading to five- and six-membered rings are to be developed based on the application of (trialkylsilyl)vinylketenes as four-carbon synthetic building blocks. The principal investigator notes that a new method for the synthesis of 2,4-cyclohexadienones is to be developed and employed as a key step in an efficient synthetic approach to an A-ring synthon for the antitumor agent taxol. It is indicated that part II of the proposal describes the further development of a general regiocontrolled annulation route to highly substituted aromatic and heteroaromatic compounds. The principal investigator notes that the application of this methodology to the total synthesis of biologically active natural products will be studied and that specific target compounds include the antibiotic phenalenone diterpene atrovenetin, the hypocholesterolemic antibiotic ascochlorin, and the antineoplastic diterpene taxmairin B and that in addition, the application of an intramolecular enyne cycloaddition strategy to the total synthesis of the tetracyclic furanophenalenone diterpene salvilenone will also be examined.